Outcomes after simultaneous pancreas-kidney transplantation from donation after circulatory death donors: A UK registry analysis.
clinical research / practice
diabetes
donors and donation: donation after circulatory death (DCD)
organ procurement and allocation
pancreas / simultaneous pancreas-kidney transplantation
registry / registry analysis
statistics
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
06
04
2021
received:
02
11
2020
accepted:
07
04
2021
pubmed:
20
4
2021
medline:
12
11
2021
entrez:
19
4
2021
Statut:
ppublish
Résumé
There are concerns that simultaneous pancreas-kidney (SPK) transplants from donation after circulatory death (DCD) donors have a higher risk of graft failure than those from donation after brain death (DBD) donors. A UK registry analysis of SPK transplants between 2005 and 2018 was performed. Pancreas survivals of those receiving organs from DCD or DBD donors were compared. Multivariable analyses were used to adjust for baseline differences between the two groups and to identify factors associated with pancreas graft loss. A total of 2228 SPK transplants were implanted; 403 (18.1%) were from DCD donors. DCD donors were generally younger, slimmer, less likely to have stroke as a cause of death, with lower terminal creatinines and shorter pancreas cold ischemic times than DBD donors. Median (IQR) follow-up was 4.2 (1.6-8.1) years. On univariable analysis, there were no statistically significant differences in 5-year death-censored pancreas graft survival between the two donor types (79.5% versus 80.4%; p = .86). Multivariable analysis showed no statistically significant differences in 5-year pancreas graft loss between transplants from DCD (n = 343) and DBD (n = 1492) donors (hazard ratio 1.26, 95% CI 0.76-1.23; p = .12). The findings from this study support the increased use of SPK transplants from DCD donors.
Identifiants
pubmed: 33870619
doi: 10.1111/ajt.16604
pii: S1600-6135(22)08799-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3673-3683Informations de copyright
© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons.
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