The Role of Home-Based Exercise in Maintaining Skeletal Muscle During Preoperative Pancreatic Cancer Treatment.

body composition chemotherapy prehabilitation skeletal muscle density skeletal muscle index

Journal

Integrative cancer therapies
ISSN: 1552-695X
Titre abrégé: Integr Cancer Ther
Pays: United States
ID NLM: 101128834

Informations de publication

Date de publication:
Historique:
entrez: 19 4 2021
pubmed: 20 4 2021
medline: 12 10 2021
Statut: ppublish

Résumé

Loss of skeletal muscle and inferior muscle quality are associated with poor prognosis in patients undergoing preoperative treatment for pancreatic cancer, so maintaining skeletal muscle health before surgery may help accelerate patients' functional recovery and improve their quality of life following surgery. While exercise helps maintain or increase skeletal muscle in individuals undergoing cancer treatment, its efficacy during pancreatic cancer treatment is unclear. Accordingly, in this study we compared changes in skeletal muscle quantity (skeletal muscle index [SMI]) and quality (skeletal muscle density [SMD]) during preoperative pancreatic cancer treatment in participants in a home-based exercise program (EP) and a historical cohort of patients who received the usual care (UC) with no formal exercise programming. Recommendations for the EP cohort included both aerobic and resistance exercise. We assessed changes in SMI and SMD using computed tomography scans administered at treatment planning (T0, prior to EP enrollment) and preoperative restaging (T1) for 33 EP and 64 UC patients and compared changes between groups. The UC patients had statistically significant SMI decreases from T0 to T1 (-1.4 ± 3.8 cm

Identifiants

pubmed: 33870744
doi: 10.1177/1534735420986615
pmc: PMC8056559
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1534735420986615

Subventions

Organisme : NCI NIH HHS
ID : R21 CA218732
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : R25 CA203650
Pays : United States

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Auteurs

Nathan H Parker (NH)

MD Anderson Cancer Center, Houston, TX, USA.

Jessica Gorzelitz (J)

University of Wisconsin, Madison, WI, USA.

An Ngo-Huang (A)

MD Anderson Cancer Center, Houston, TX, USA.

Bette J Caan (BJ)

Kaiser Permanente Northern California, Oakland, CA, USA.

Laura Prakash (L)

MD Anderson Cancer Center, Houston, TX, USA.

Naveen Garg (N)

MD Anderson Cancer Center, Houston, TX, USA.

Maria Q B Petzel (MQB)

MD Anderson Cancer Center, Houston, TX, USA.

Keri Schadler (K)

MD Anderson Cancer Center, Houston, TX, USA.

Karen Basen-Engquist (K)

MD Anderson Cancer Center, Houston, TX, USA.

Matthew H G Katz (MHG)

MD Anderson Cancer Center, Houston, TX, USA.

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Classifications MeSH