Improved diet quality is associated with decreased concentrations of inflammatory markers in adults with uncontrolled asthma.
DASH diet
asthma
blood proteins
cytokines
inflammatory markers
Journal
The American journal of clinical nutrition
ISSN: 1938-3207
Titre abrégé: Am J Clin Nutr
Pays: United States
ID NLM: 0376027
Informations de publication
Date de publication:
01 09 2021
01 09 2021
Historique:
received:
07
07
2020
accepted:
19
02
2021
pubmed:
20
4
2021
medline:
2
10
2021
entrez:
19
4
2021
Statut:
ppublish
Résumé
Asthma has become one of the major public health challenges, and recent studies show promising clinical benefits of dietary interventions, such as the Dietary Approaches to Stop Hypertension (DASH) diet. The objective of this study was to examine whether changes in diet quality are associated with changes in inflammatory markers important in asthma pathophysiology. In this exploratory study in patients with poorly controlled asthma participating in a randomized controlled trial of a DASH intervention study, changes in concentrations of a broad panel of serum proteins (51-plex Luminex assay, Affymetrix) were determined, and their relation to diet quality (DASH score) assessed by combining data of both intervention and usual-care control groups. Second, the relation between the serum proteins, other biomarkers of inflammation and nutrition, and Asthma Control Questionnaire (ACQ) was assessed. During the first 3 mo, diet quality (DASH scores) were inversely associated (P < 0.05, false discovery rate P < 0.09) with serum concentrations of a large number serum proteins, reflecting not only general proinflammatory markers such as IL-1β, transforming growth factor α (TGF-α), and IL-6 (r = -0.31 to -0.39) but also a number of proteins associated with asthmatic conditions, specifically several T-helper (Th) 2 (Th2; r = -0.29 to -0.34) and Th17 (r = -0.4) associated cytokines and growth factors. Monokine induced by gamma/chemokine (C-X-C motif) ligand 9 (CXCL9) (MIG/CXCL9), a T-cell attractant induced by IFN-γ previously linked to asthma exacerbations, appeared to be the marker most consistently associated with DASH diet quality for the entire 6-mo study period (r = -0.40 and -0.30 for 0-3 and 3-6 mo, respectively, and standardized coefficient loadings -0.13 in the partial least squares analyses). Decreases in 19 serum protein concentrations were also correlated with improved asthma control during the 6-mo study period. Our data in adult patients with poorly controlled asthma suggest that dietary changes, like the introduction of DASH, may have beneficial effects on reducing inflammatory status. This trial was registered at http://www.clinicaltrials.gov as NCT01725945.
Sections du résumé
BACKGROUND
Asthma has become one of the major public health challenges, and recent studies show promising clinical benefits of dietary interventions, such as the Dietary Approaches to Stop Hypertension (DASH) diet.
OBJECTIVE
The objective of this study was to examine whether changes in diet quality are associated with changes in inflammatory markers important in asthma pathophysiology.
METHODS
In this exploratory study in patients with poorly controlled asthma participating in a randomized controlled trial of a DASH intervention study, changes in concentrations of a broad panel of serum proteins (51-plex Luminex assay, Affymetrix) were determined, and their relation to diet quality (DASH score) assessed by combining data of both intervention and usual-care control groups. Second, the relation between the serum proteins, other biomarkers of inflammation and nutrition, and Asthma Control Questionnaire (ACQ) was assessed.
RESULTS
During the first 3 mo, diet quality (DASH scores) were inversely associated (P < 0.05, false discovery rate P < 0.09) with serum concentrations of a large number serum proteins, reflecting not only general proinflammatory markers such as IL-1β, transforming growth factor α (TGF-α), and IL-6 (r = -0.31 to -0.39) but also a number of proteins associated with asthmatic conditions, specifically several T-helper (Th) 2 (Th2; r = -0.29 to -0.34) and Th17 (r = -0.4) associated cytokines and growth factors. Monokine induced by gamma/chemokine (C-X-C motif) ligand 9 (CXCL9) (MIG/CXCL9), a T-cell attractant induced by IFN-γ previously linked to asthma exacerbations, appeared to be the marker most consistently associated with DASH diet quality for the entire 6-mo study period (r = -0.40 and -0.30 for 0-3 and 3-6 mo, respectively, and standardized coefficient loadings -0.13 in the partial least squares analyses). Decreases in 19 serum protein concentrations were also correlated with improved asthma control during the 6-mo study period.
CONCLUSIONS
Our data in adult patients with poorly controlled asthma suggest that dietary changes, like the introduction of DASH, may have beneficial effects on reducing inflammatory status. This trial was registered at http://www.clinicaltrials.gov as NCT01725945.
Identifiants
pubmed: 33871602
pii: S0002-9165(22)00425-7
doi: 10.1093/ajcn/nqab063
pmc: PMC8578836
doi:
Substances chimiques
Biomarkers
0
Blood Proteins
0
Cytokines
0
Banques de données
ClinicalTrials.gov
['NCT01725945']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1012-1027Subventions
Organisme : NHLBI NIH HHS
ID : R34 HL108753
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.
Références
J Allergy Clin Immunol. 1997 Sep;100(3):408-14
pubmed: 9314355
Lancet Respir Med. 2016 Jul;4(7):574-584
pubmed: 27283230
J Allergy Clin Immunol. 2016 Oct;138(4):984-1010
pubmed: 27577879
Allergy. 2019 Apr;74(4):799-809
pubmed: 30390309
J Am Diet Assoc. 1999 Aug;99(8 Suppl):S19-27
pubmed: 10450290
Am J Clin Nutr. 2006 Oct;84(4):748-55
pubmed: 17023700
Ann Nutr Metab. 2014;64(1):20-7
pubmed: 24686130
Eur Respir J. 2016 Jan;47(1):122-32
pubmed: 26493792
J Asthma. 2018 Feb;55(2):111-118
pubmed: 28399677
Arch Intern Med. 2008 Feb 11;168(3):308-14
pubmed: 18268173
Ann Thorac Surg. 2016 May;101(5):1644-5
pubmed: 27106412
PLoS One. 2013 Jul 09;8(7):e68290
pubmed: 23874577
J Allergy Clin Immunol. 2004 Jan;113(1):59-65
pubmed: 14713908
Thorax. 2009 Jul;64(7):610-9
pubmed: 19406861
Nat Commun. 2019 Dec 13;10(1):5711
pubmed: 31836714
Public Health Nutr. 2010 Sep;13(9):1395-402
pubmed: 20003635
Arch Intern Med. 2008 Apr 14;168(7):713-20
pubmed: 18413553
Br J Nutr. 2011 Aug;106(3):441-50
pubmed: 21443816
Am J Clin Nutr. 2003 May;77(5):1171-8
pubmed: 12716668
J Allergy Clin Immunol Pract. 2018 May - Jun;6(3):751-763
pubmed: 29221919
Inflammation. 2017 Aug;40(4):1225-1235
pubmed: 28429138
Pediatr Int. 2008 Feb;50(1):99-102
pubmed: 18279215
Eur Respir J. 1999 Oct;14(4):902-7
pubmed: 10573240
Contemp Clin Trials. 2013 Jul;35(2):55-67
pubmed: 23648395
J Am Diet Assoc. 2009 Mar;109(3):414-21
pubmed: 19248856
J Asthma Allergy. 2014 Aug 12;7:105-21
pubmed: 25143747
Pak J Med Sci. 2016 May-Jun;32(3):700-4
pubmed: 27375717
Respir Res. 2015 Jan 24;16:5
pubmed: 25616863
J Immunol Methods. 2009 Jan 1;340(1):33-41
pubmed: 18952093
J Allergy Clin Immunol. 2015 Feb;135(2):386-94
pubmed: 25312760
Clin Nutr. 2018 Apr;37(2):542-550
pubmed: 28302405
Am J Clin Nutr. 2012 Sep;96(3):534-43
pubmed: 22854412