Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis.
Attention deficit disorder with hyperactivity
Meta-analysis
Polycystic ovary syndrome
Journal
Clinical and experimental pediatrics
ISSN: 2713-4148
Titre abrégé: Clin Exp Pediatr
Pays: Korea (South)
ID NLM: 101761234
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
13
02
2021
accepted:
31
03
2021
pubmed:
20
4
2021
medline:
20
4
2021
entrez:
19
4
2021
Statut:
ppublish
Résumé
There is evidence of a relationship between prenatal excess androgen exposure and central nervous developmental problems and attention-deficit/hyperactivity disorder (ADHD) in the offspring of mothers with polycystic ovary syndrome (PCOS). Here we aimed to use a meta-analysis to investigate whether the offspring of mothers with PCOS are at an increased chance of developing ADHD. Three main English databases were searched for articles published through December 2020. The NewcastleOttawa Scale was used to assess study quality. Study heterogeneity was determined using <italic>I</italic>2 statistics and publication bias was assessed using Begg and Egger tests. The results are presented as odds ratio (OR) and relative ratio (RR) estimates with 95% confidence intervals (CIs) using a random-effects model. Six articles (3 cohort and 3 case-control studies; 401,413 total ADHD cases) met the study criteria. Maternal PCOS was associated with an increased risk of ADHD in the offspring based on OR and RR (OR, 1.42; 95% CI, 1.27-1.57) and (RR, 1.43; 95% CI, 1.35-1.51), respectively. There was no heterogeneity among the included articles based on OR (<italic>I</italic>2=0.0%, P=0.588) and RR (<italic>I</italic>2=0.0%, P=0.878). Our study showed that maternal PCOS is a risk factor for ADHD. Therefore, screening their offspring for ADHD should be considered part of the comprehensive clinical care of women with PCOS.
Sections du résumé
BACKGROUND
BACKGROUND
There is evidence of a relationship between prenatal excess androgen exposure and central nervous developmental problems and attention-deficit/hyperactivity disorder (ADHD) in the offspring of mothers with polycystic ovary syndrome (PCOS).
PURPOSE
OBJECTIVE
Here we aimed to use a meta-analysis to investigate whether the offspring of mothers with PCOS are at an increased chance of developing ADHD.
METHODS
METHODS
Three main English databases were searched for articles published through December 2020. The NewcastleOttawa Scale was used to assess study quality. Study heterogeneity was determined using <italic>I</italic>2 statistics and publication bias was assessed using Begg and Egger tests. The results are presented as odds ratio (OR) and relative ratio (RR) estimates with 95% confidence intervals (CIs) using a random-effects model.
RESULTS
RESULTS
Six articles (3 cohort and 3 case-control studies; 401,413 total ADHD cases) met the study criteria. Maternal PCOS was associated with an increased risk of ADHD in the offspring based on OR and RR (OR, 1.42; 95% CI, 1.27-1.57) and (RR, 1.43; 95% CI, 1.35-1.51), respectively. There was no heterogeneity among the included articles based on OR (<italic>I</italic>2=0.0%, P=0.588) and RR (<italic>I</italic>2=0.0%, P=0.878).
CONCLUSION
CONCLUSIONS
Our study showed that maternal PCOS is a risk factor for ADHD. Therefore, screening their offspring for ADHD should be considered part of the comprehensive clinical care of women with PCOS.
Identifiants
pubmed: 33872487
pii: cep.2021.00178
doi: 10.3345/cep.2021.00178
pmc: PMC8841975
doi:
Types de publication
Journal Article
Langues
eng
Pagination
85-89Subventions
Organisme : Hamadan University of Medical Sciences
ID : 9911218343
Commentaires et corrections
Type : CommentIn
Références
Hum Reprod. 2015 Mar;30(3):692-700
pubmed: 25609240
Mol Psychiatry. 2019 Dec;24(12):1787-1797
pubmed: 30867561
Expert Rev Neurother. 2016;16(3):279-93
pubmed: 26807870
Int J Psychiatry Med. 2015;50(3):317-25
pubmed: 26449924
Acta Psychiatr Scand. 2020 Oct;142(4):275-283
pubmed: 32056200
PLoS One. 2015 Aug 28;10(8):e0136540
pubmed: 26317406
Hum Reprod. 2020 Oct 1;35(10):2336-2347
pubmed: 32866965
Pediatrics. 2015 Apr;135(4):e994-1001
pubmed: 25733754
Asian Pac J Cancer Prev. ;18(1):17-21
pubmed: 28240001
F1000Res. 2019 Dec 5;8:
pubmed: 31824658
Curr Psychiatry Rep. 2017 Jan;19(1):1
pubmed: 28091799
Eur J Obstet Gynecol Reprod Biol. 2013 Feb;166(2):151-5
pubmed: 23122578
Psychol Med. 2020 Mar;50(4):616-624
pubmed: 30857571
Fertil Steril. 2013 Sep;100(3):844-53
pubmed: 23810272
Fertil Steril. 2020 Feb;113(2):435-443
pubmed: 32106995
Hum Reprod. 2018 Jul 1;33(7):1307-1315
pubmed: 29668891
Am J Psychiatry. 2019 Jan 1;176(1):57-66
pubmed: 30220220
Fertil Steril. 2004 Jan;81(1):19-25
pubmed: 14711538
Crit Rev Food Sci Nutr. 2008 Jun;48(6):524-37
pubmed: 18568858
Biol Psychiatry. 2017 Nov 1;82(9):651-659
pubmed: 27889187
Prim Care Companion CNS Disord. 2014;16(3):
pubmed: 25317367
Am J Obstet Gynecol. 2011 Jun;204(6):558.e1-6
pubmed: 21752757
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
Diabetes Care. 2018 Dec;41(12):2502-2508
pubmed: 30373735
Korean J Pediatr. 2019 Oct;62(10):374-379
pubmed: 31208166
J Clin Endocrinol Metab. 2018 Jun 1;103(6):2116-2125
pubmed: 29648599
Psychiatry Res. 2019 Feb;272:765-773
pubmed: 30832197
J Atten Disord. 2011 Jan;15(1):3-10
pubmed: 20418468