The synaptic life of microtubules.
Journal
Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
06
02
2021
revised:
03
03
2021
accepted:
08
03
2021
pubmed:
20
4
2021
medline:
14
9
2021
entrez:
19
4
2021
Statut:
ppublish
Résumé
In neurons, control of microtubule dynamics is required for multiple homeostatic and regulated activities. Over the past few decades, a great deal has been learned about the role of the microtubule cytoskeleton in axonal and dendritic transport, with a broad impact on neuronal health and disease. However, significantly less attention has been paid to the importance of microtubule dynamics in directly regulating synaptic function. Here, we review emerging literature demonstrating that microtubules enter synapses and control central aspects of synaptic activity, including neurotransmitter release and synaptic plasticity. The pleiotropic effects caused by a dysfunctional synaptic microtubule cytoskeleton may thus represent a key point of vulnerability for neurons and a primary driver of neurological disease.
Identifiants
pubmed: 33873059
pii: S0959-4388(21)00023-4
doi: 10.1016/j.conb.2021.03.004
pmc: PMC8387337
mid: NIHMS1684865
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
113-123Subventions
Organisme : NINDS NIH HHS
ID : R21 NS120076
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG060025
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG050658
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS080967
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG069941
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest statement Nothing declared.
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