Human Tissue Distribution of Anidulafungin and Micafungin.
antifungal target-site penetration
echinocandins
invasive candidiasis
tissue distribution
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
17 06 2021
17 06 2021
Historique:
pubmed:
21
4
2021
medline:
29
6
2021
entrez:
20
4
2021
Statut:
ppublish
Résumé
Concentrations of anidulafungin and micafungin were determined in eight different tissues obtained during autopsy of four deceased individuals who had been treated with anidulafungin and of seven who had received micafungin. The largest amounts were recovered from liver, with anidulafungin concentrations of 11.01 to 66.50 μg/g and micafungin levels of 0.36 to 5.53 μg/g (0.65 μg/g 30 days after the last administration). The lowest anidulafungin levels were measured in skeletal muscle, and the lowest micafungin concentrations were in kidneys.
Identifiants
pubmed: 33875434
pii: AAC.00169-21
doi: 10.1128/AAC.00169-21
pmc: PMC8218649
doi:
Substances chimiques
Antifungal Agents
0
Echinocandins
0
Lipopeptides
0
Anidulafungin
9HLM53094I
Micafungin
R10H71BSWG
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0016921Subventions
Organisme : Austrian Science Fund FWF
ID : KLI 565
Pays : Austria
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