GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis.
Animals
Chemokine CXCL10
Chemokine CXCL12
Chemokine CXCL13
Chemokines
/ metabolism
Endothelial Cells
/ metabolism
Female
HEK293 Cells
Hematopoietic Stem Cells
/ metabolism
Homeostasis
Humans
Male
Mice
Mice, Inbred C57BL
Receptors, Chemokine
/ metabolism
Receptors, G-Protein-Coupled
/ genetics
Signal Transduction
/ physiology
beta-Arrestins
/ metabolism
GPCR
chemokine
orphan
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
27 04 2021
27 04 2021
Historique:
entrez:
20
4
2021
pubmed:
21
4
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
G protein-coupled receptor 182 (GPR182) has been shown to be expressed in endothelial cells; however, its ligand and physiological role has remained elusive. We found GPR182 to be expressed in microvascular and lymphatic endothelial cells of most organs and to bind with nanomolar affinity the chemokines CXCL10, CXCL12, and CXCL13. In contrast to conventional chemokine receptors, binding of chemokines to GPR182 did not induce typical downstream signaling processes, including G
Identifiants
pubmed: 33875597
pii: 2021596118
doi: 10.1073/pnas.2021596118
pmc: PMC8092405
pii:
doi:
Substances chimiques
CXCL12 protein, human
0
CXCL13 protein, human
0
Chemokine CXCL10
0
Chemokine CXCL12
0
Chemokine CXCL13
0
Chemokines
0
GPR182 protein, human
0
Receptors, Chemokine
0
Receptors, G-Protein-Coupled
0
beta-Arrestins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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