The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway.
3T3-L1 fibroblasts
AMPK
ORM
TGF-β1
adipose tissue
dorsomorphin
fibrosis
metabolic disorders
obesity
Journal
Acta pharmacologica Sinica
ISSN: 1745-7254
Titre abrégé: Acta Pharmacol Sin
Pays: United States
ID NLM: 100956087
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
22
10
2020
accepted:
22
03
2021
pubmed:
21
4
2021
medline:
17
3
2022
entrez:
20
4
2021
Statut:
ppublish
Résumé
The excess deposition of underlying extracellular matrix (ECM) in adipose tissue is defined as adipose tissue fibrosis that is a major contributor to metabolic disorder such as obesity and type 2 diabetes. Anti-fibrosis therapy has received much attention in the treatment of metabolic disorders. Orosomucoid (ORM) is an acute-phase protein mainly produced by liver, which is also an adipokine. In this study, we investigated the effects of ORM on adipose tissue fibrosis and the potential mechanisms. We showed that ORM1-deficient mice exhibited an obese phenotype, manifested by excessive collagen deposition in adipose tissues and elevated expression of ECM regulators such as metalloproteinases (MMP-2, MMP-13, MMP-14) and tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2, TIMP-3). Administration of exogenous ORM (50 mg· kg
Identifiants
pubmed: 33875797
doi: 10.1038/s41401-021-00666-9
pii: 10.1038/s41401-021-00666-9
pmc: PMC8792011
doi:
Substances chimiques
Adipokines
0
Orosomucoid
0
AMP-Activated Protein Kinases
EC 2.7.11.31
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
367-375Informations de copyright
© 2021. The Author(s), under exclusive licence to CPS and SIMM.
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