Occupational exposure to pesticides and central nervous system tumors: results from the CERENAT case-control study.
Adult
Aged
Agriculture
Brain Neoplasms
/ chemically induced
Case-Control Studies
Central Nervous System Neoplasms
/ chemically induced
Female
France
/ epidemiology
Glioma
/ chemically induced
Humans
Logistic Models
Male
Meningeal Neoplasms
/ chemically induced
Meningioma
/ chemically induced
Middle Aged
Occupational Diseases
/ chemically induced
Occupational Exposure
/ adverse effects
Odds Ratio
Parks, Recreational
Pesticides
/ adverse effects
Risk Factors
Agriculture
Central nervous system tumor
Etiology
Glioma
Green spaces
Meningioma
Occupational exposures
Pesticides
Journal
Cancer causes & control : CCC
ISSN: 1573-7225
Titre abrégé: Cancer Causes Control
Pays: Netherlands
ID NLM: 9100846
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
17
10
2020
accepted:
30
03
2021
pubmed:
21
4
2021
medline:
13
7
2021
entrez:
20
4
2021
Statut:
ppublish
Résumé
The etiology of the central nervous system (CNS) tumors remains largely unknown. The role of pesticide exposure has been suggested by several epidemiological studies, but with no definitive conclusion. To analyze associations between occupational pesticide exposure and primary CNS tumors in adults in the CERENAT study. CERENAT is a multicenter case-control study conducted in France in 2004-2006. Data about occupational pesticide uses-in and outside agriculture-were collected during detailed face-to-face interviews and reviewed by experts for consistency and exposure assignment. Odds ratios (ORs) and 95% confidence intervals (95% CI) were estimated with conditional logistic regression. A total of 596 cases (273 gliomas, 218 meningiomas, 105 others) and 1 192 age- and sex-matched controls selected in the general population were analyzed. Direct and indirect exposures to pesticides in agriculture were respectively assigned to 125 (7.0%) and 629 (35.2%) individuals and exposure outside agriculture to 146 (8.2%) individuals. For overall agricultural exposure, we observed no increase in risk for all brain tumors (OR 1.04, 0.69-1.57) and a slight increase for gliomas (OR 1.37, 0.79-2.39). Risks for gliomas were higher when considering agricultural exposure for more than 10 years (OR 2.22, 0.94-5.24) and significantly trebled in open field agriculture (OR 3.58, 1.20-10.70). Increases in risk were also observed in non-agricultural exposures, especially in green space workers who were directly exposed (OR 1.89, 0.82-4.39), and these were statistically significant for those exposed for over 10 years (OR 2.84, 1.15-6.99). These data support some previous findings regarding the potential role of occupational exposures to pesticides in CNS tumors, both inside and outside agriculture.
Sections du résumé
BACKGROUND
BACKGROUND
The etiology of the central nervous system (CNS) tumors remains largely unknown. The role of pesticide exposure has been suggested by several epidemiological studies, but with no definitive conclusion.
OBJECTIVE
OBJECTIVE
To analyze associations between occupational pesticide exposure and primary CNS tumors in adults in the CERENAT study.
METHODS
METHODS
CERENAT is a multicenter case-control study conducted in France in 2004-2006. Data about occupational pesticide uses-in and outside agriculture-were collected during detailed face-to-face interviews and reviewed by experts for consistency and exposure assignment. Odds ratios (ORs) and 95% confidence intervals (95% CI) were estimated with conditional logistic regression.
RESULTS
RESULTS
A total of 596 cases (273 gliomas, 218 meningiomas, 105 others) and 1 192 age- and sex-matched controls selected in the general population were analyzed. Direct and indirect exposures to pesticides in agriculture were respectively assigned to 125 (7.0%) and 629 (35.2%) individuals and exposure outside agriculture to 146 (8.2%) individuals. For overall agricultural exposure, we observed no increase in risk for all brain tumors (OR 1.04, 0.69-1.57) and a slight increase for gliomas (OR 1.37, 0.79-2.39). Risks for gliomas were higher when considering agricultural exposure for more than 10 years (OR 2.22, 0.94-5.24) and significantly trebled in open field agriculture (OR 3.58, 1.20-10.70). Increases in risk were also observed in non-agricultural exposures, especially in green space workers who were directly exposed (OR 1.89, 0.82-4.39), and these were statistically significant for those exposed for over 10 years (OR 2.84, 1.15-6.99).
DISCUSSION
CONCLUSIONS
These data support some previous findings regarding the potential role of occupational exposures to pesticides in CNS tumors, both inside and outside agriculture.
Identifiants
pubmed: 33876308
doi: 10.1007/s10552-021-01429-x
pii: 10.1007/s10552-021-01429-x
doi:
Substances chimiques
Pesticides
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
773-782Références
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