Associations Between Patterns of Alcohol Use and Viral Load Suppression Amongst Women Living with HIV in South Africa.

Alcohol Drinking / epidemiology Ethanol Female HIV Infections / drug therapy Humans South Africa / epidemiology Viral Load
Alcohol HIV Mediators South Africa Viral load suppression Women

Journal

AIDS and behavior
ISSN: 1573-3254
Titre abrégé: AIDS Behav
Pays: United States
ID NLM: 9712133

Informations de publication

Date de publication:
Nov 2021
Historique:
accepted: 12 04 2021
pubmed: 21 4 2021
medline: 4 11 2021
entrez: 20 4 2021
Statut: ppublish

Résumé

This study aimed to identify alcohol use patterns associated with viral non-suppression among women living with HIV (WLWH) and the extent to which adherence mediated these relationships. Baseline data on covariates, alcohol consumption, ART adherence, and viral load were collected from 608 WLWH on ART living in the Western Cape, South Africa. We defined three consumption patterns: no/light drinking (drinking ≤ 1/week and ≤ 4 drinks/occasion), occasional heavy episodic drinking (HED) (drinking > 1 and ≤ 2/week and ≥ 5 drinks/occasion) and frequent HED (drinking ≥ 3 times/week and ≥ 5 drinks/occasion). In multivariable analyses, occasional HED (OR 3.07, 95% CI 1.78-5.30) and frequent HED (OR 7.11, 95% CI 4.24-11.92) were associated with suboptimal adherence. Frequent HED was associated with viral non-suppression (OR 2.08, 95% CI 1.30-3.28). Suboptimal adherence partially mediated the relationship between frequent HED and viral non-suppression. Findings suggest a direct relationship between frequency of HED and viral suppression. Given the mediating effects of adherence on this relationship, alcohol interventions should be tailored to frequency of HED while also addressing adherence.

Identifiants

DOI: 10.1007/s10461-021-03263-3 PMID: 33876383 PMC: PMC8560660
pubmed: 33876383
doi: 10.1007/s10461-021-03263-3
pii: 10.1007/s10461-021-03263-3
pmc: PMC8560660
doi:

Substances chimiques

Ethanol 3K9958V90M

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3758-3769

Subventions

Organisme : Medical Research Council
ID : MR/M014290/1
Pays : United Kingdom

Informations de copyright

© 2021. The Author(s).

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Auteurs

B Myers (B)

Alcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Tygerberg, PO Box 19070, Cape Town, 7505, South Africa. bmyers@mrc.ac.za.
Department of Psychiatry & Mental Health, University of Cape Town, Cape Town, South Africa. bmyers@mrc.ac.za.
ORCID: 0000-0003-0235-6716

C Lombard (C)

Biostatistics Unit, South African Medical Research Council, Cape Town, South Africa.

J A Joska (JA)

Department of Psychiatry & Mental Health, University of Cape Town, Cape Town, South Africa.

F Abdullah (F)

Office of AIDS and TB Research, South African Medical Research Council, Pretoria, South Africa.

T Naledi (T)

Dean's Office, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa.

C Lund (C)

Department of Psychiatry & Mental Health, Alan J Flisher Centre for Public Mental Health, University of Cape Town, Cape Town, South Africa.

P Petersen Williams (P)

Alcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Tygerberg, PO Box 19070, Cape Town, 7505, South Africa.
Department of Psychiatry & Mental Health, University of Cape Town, Cape Town, South Africa.

D J Stein (DJ)

Department of Psychiatry & Mental Health, University of Cape Town, Cape Town, South Africa.
South African Medical Research Council's Unit on Risk & Resilience in Mental Disorders, Cape Town, South Africa.

K R Sorsdahl (KR)

Department of Psychiatry & Mental Health, Alan J Flisher Centre for Public Mental Health, University of Cape Town, Cape Town, South Africa.

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Classifications MeSH

questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement dipsique › Consommation d'alcool › Associations Between Patterns of Alcohol Use...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Associations Between Patterns of Alcohol Use...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Associations Between Patterns of Alcohol Use...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Associations Between Patterns of Alcohol Use...
questionsmedicales.fr › Régions géographiques › Afrique › Afrique subsaharienne › Afrique australe › République d'Afrique du Sud › Associations Between Patterns of Alcohol Use...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Charge virale › Associations Between Patterns of Alcohol Use...