Effect of contrast agent viscosity and massage on success of computed tomography lymphangiography with aqueous contrast for sentinel lymph node identification in healthy dogs.
metastasis
surgical oncology
tumour staging
Journal
Veterinary and comparative oncology
ISSN: 1476-5829
Titre abrégé: Vet Comp Oncol
Pays: England
ID NLM: 101185242
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
revised:
26
02
2021
received:
15
09
2020
accepted:
15
04
2021
pubmed:
21
4
2021
medline:
27
1
2022
entrez:
20
4
2021
Statut:
ppublish
Résumé
Sentinel lymph node (SLN) evaluation is important for accurate cancer staging. Computed tomography (CT) lymphangiography with aqueous contrast is a feasible technique for SLN identification in dogs. Although most studies report success rates around 90%, success rates as low as 60% have been reported. One reason for low success rates may be the difference in viscosity of the various agents used in comparison to normal lymph viscosity. The objective of this study was to evaluate contrast agents of differing viscosities for use in CT lymphangiography for SLN identification and to determine the influence of massage on contrast flow rates. The hypothesis was that lower viscosity agents would have a higher success rate and faster time to identification of the SLN than higher viscosity agents and that massage would increase contrast flow rates. Dogs were anaesthetised and CT lymphangiography was performed with four contrast agents of differing viscosities in a randomized crossover design. Injections were made on the dorsal pes bilaterally on two study days and the popliteal lymph nodes were evaluated for contrast uptake. There was no significant difference in success of SLN identification or time to SLN identification among the four agents. Massage of the injection site increased rate of contrast flow through the lymphatics. No specific recommendation for one contrast agent over another can be made with these results. Massage is recommended to improve lymphatic flow when performing CT lymphangiography with aqueous contrast in dogs.
Substances chimiques
Contrast Media
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
587-592Subventions
Organisme : Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia
Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
Worley DR. Incorporation of sentinel lymph node mapping in dogs with mast cell tumours: 20 consecutive procedures. Vet Comp Oncol. 2014;12:215-226.
Reintgen M, Kerivan L, Reintgen E, Swaninathan S, Reintgen D. Breast lymphatic mapping and sentinel lymph node biopsy: state of the art: 2015. Clin Breast Cancer. 2016;16:155-165.
Brissot HN, Edery EG. Use of indirect lymphography to identify sentinel lymph node in dogs: a pilot study in 30 tumours. Vet Comp Oncol. 2017;15(3):740-753.
Grimes JA, Secrest SA, Northrup NC, Saba CF, Schmiedt CW. Indirect computed tomography lymphangiography with aqueous contrast for evaluation of sentinel lymph nodes in dogs with tumors of the head. Vet Radiol Ultrasound. 2017;58(5):559-564.
Majeski SA, Steffey MA, Fuller M, Hunt GB, Mayhew PD, Pollard RE. Indirect computed tomographic lymphography for iliosacral lymphatic mapping in a cohort of dogs with anal sac glan adenocarcinoma: technique description. Vet Radiol Ultrasound. 2017;58(3):295-303.
Rossi F, Körner M, Suárez J, et al. Computed tomographic-lymphography as a complementary technique for lymph node staging in dogs with malignant tumors of various sites. Vet Radiol Ultrasound. 2018;59(2):155-162.
Soultani C, Patsikas MN, Karayannopoulou M, et al. Assessment of sentinel lymph node metastasis in canine mammary gland tumors using computed tomographic indirect lymphography. Vet Radiol Ultrasound. 2017;58(2):186-196.
Sugiyama S, Iwai T, Izumi T, et al. CT lymphography for sentinel lymph node mapping of clinically N0 early oral cancer. Cancer Imaging. 2019;19:72.
Tanahashi Y, Iwasaki R, Shoda S, et al. Dynamic contrast-enhanced computed tomography lymphangiography with intranodal injection of water-soluble iodine contrast media in microminipig: imaging protocol and feasibility. Eur Radiol. 2020;30(5):5913-5922.
Millward IR, Kirberger RM, Thompson PN. Comparative popliteal and mesenteric computed tomography lymphangiography of the canine thoracic duct. Vet Radiol Ultrasound. 2011;52(3):295-301.
Hayashi K, Sicard G, Gellasch K, Frank JD, Hardie RJ, McAnulty JF. Cisterna chyli ablation with thoracic duct ligation for chylothorax: results in eight dogs. Vet Surg. 2005;34:519-523.
Burton-Opitz R, Nemser R. The viscosity of lymph. Am J Physiol. 1917;45(1):25-29.
The Royal Australian and New Zealand College of Radiologists. Notes on Radiographic Contrast Agents. www.ranzcr.com. Accessed August 12, 2018.
Federal Drug Administration. Lipiodol. https://www.accessdata.fda.gov. Accessed August 15, 2018.
Random.org Random Integer Set Generator. www.random.org. Accessed January 31, 2019.
Ikomi F, Hunt J, Hanna G, Schmid-Schönbein GW. Interstitial fluid, plasma protein, colloid, and leukocyte uptake into initial lymphatics. J Appl Physiol. 1996;81(5):2060-2067.
Bass SS, Cox CE, Salud CJ, et al. The effects of postinjection massage on the sensitivity of lymphatic mapping in breast cancer. J Am Coll Surg. 2001;192:9-16.
Kirby RM, Basit A, Nguyen QT, Jaipersad A, Billingham R. Three stage axillary lymphatic massage optimizes sentinel lymph node localisation using blue dye. Int Semin Surg Oncol. 2007;4:30.
Jakub JW, Cox CE, Pippas AW, Gardner M, Pendas S, Reintgen DS. Controversial topics in breast lymphatic mapping. Semin Oncol. 2004;31:324-332.
Diaz NM, Vrcel V, Centeno BA, Muro-Cacho C. Modes of benign mechanical transport of breast epithelial cells to axillary lymph nodes. Adv Anat Pathol. 2005;12(1):7-9.
Randall EK, Jones MD, Kraft SL, Worley DR. The development of an indirect computed tomography lymphography protocol for sentinel lymph node detection in head and neck cancer and comparison to other sentinel lymph node mapping techniques. Vet Comp Oncol. 2020;18(4):634-644. https://doi.org/10.1111/vco.12585.
National Center for Biotechnology Information. PubChem Compound Summary for CID 3730, Iohexol. https://pubchem.ncbi.nlm.nih.gov/compound/Iohexol. Accessed Nov 19, 2020.
Schaeffer H, Kohn B, Schweigert FJ, Raila J. Quantitative and qualitative urine protein excretion in dogs with severe inflammatory response syndrome. J Vet Intern Med. 2011;25:1292-1297.