Protective antibodies against human parainfluenza virus type 3 infection.
Animals
Antibodies, Monoclonal
/ immunology
Antibodies, Neutralizing
/ immunology
Antibody Specificity
Antiviral Agents
/ immunology
B-Lymphocytes
/ immunology
Cell Line
Disease Models, Animal
Epitopes
Host-Pathogen Interactions
Humans
Immunocompromised Host
Lung
/ immunology
Parainfluenza Virus 3, Human
/ drug effects
Respirovirus Infections
/ immunology
Sigmodontinae
Viral Fusion Proteins
/ antagonists & inhibitors
Parainfluenza
fusion protein
immunosuppression
neutralizing antibodies
respiratory viruses
Journal
mAbs
ISSN: 1942-0870
Titre abrégé: MAbs
Pays: United States
ID NLM: 101479829
Informations de publication
Date de publication:
Historique:
entrez:
20
4
2021
pubmed:
21
4
2021
medline:
20
1
2022
Statut:
ppublish
Résumé
Human parainfluenza virus type III (HPIV3) is a common respiratory pathogen that afflicts children and can be fatal in vulnerable populations, including the immunocompromised. There are currently no effective vaccines or therapeutics available, resulting in tens of thousands of hospitalizations per year. In an effort to discover a protective antibody against HPIV3, we screened the B cell repertoires from peripheral blood, tonsils, and spleen from healthy children and adults. These analyses yielded five monoclonal antibodies that potently neutralized HPIV3
Identifiants
pubmed: 33876699
doi: 10.1080/19420862.2021.1912884
pmc: PMC8078717
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
Antiviral Agents
0
Epitopes
0
Viral Fusion Proteins
0
F protein, parainfluenza virus 3
109300-94-9
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1912884Subventions
Organisme : NIAID NIH HHS
ID : T32 AI118690
Pays : United States
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