A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice.
Age Factors
Aging
/ metabolism
Animals
Biomarkers
/ blood
Body Composition
Bone Remodeling
Energy Metabolism
Frailty
/ diagnostic imaging
Functional Status
Hand Strength
Insulin Resistance
Liver
/ metabolism
Longevity
Male
Metabolome
Metabolomics
Mice, Inbred C57BL
Myocardium
/ metabolism
Phenotype
Sex Factors
Walking Speed
Aging
Metabolism
Metabolomics
computational biology
gait
mouse
physiology
systems biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
20 04 2021
20 04 2021
Historique:
received:
10
09
2020
accepted:
13
04
2021
pubmed:
21
4
2021
medline:
28
10
2021
entrez:
20
4
2021
Statut:
epublish
Résumé
Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In this study, we conducted physiologic and functional tests cross-sectionally throughout the entire lifespan of male C57BL/6N mice. In parallel, metabolomics analyses in serum, brain, liver, heart, and skeletal muscle were also performed to identify signatures associated with frailty and age-dependent functional decline. Our findings indicate that declines in gait speed as a function of age and frailty are associated with a dramatic increase in the energetic cost of physical activity and decreases in working capacity. Aging and functional decline prompt organs to rewire their metabolism and substrate selection and toward redox-related pathways, mainly in liver and heart. Collectively, the data provide a framework to further understand and characterize processes of aging at the individual organism and organ levels.
Identifiants
pubmed: 33876723
doi: 10.7554/eLife.62952
pii: 62952
pmc: PMC8099423
doi:
pii:
Substances chimiques
Biomarkers
0
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
MP, IA, MK, WB, SM, CM, SS, NP, KF, RS, MS, EL, LF, MA, MB, Rd No competing interests declared
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