4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold.
epilepsy
mRNA translation
mTORC1
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
13 04 2021
13 04 2021
Historique:
entrez:
20
4
2021
pubmed:
21
4
2021
medline:
27
11
2021
Statut:
ppublish
Résumé
The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) integrates multiple signals to regulate critical cellular processes such as mRNA translation, lipid biogenesis, and autophagy. Germline and somatic mutations in mTOR and genes upstream of mTORC1, such as
Identifiants
pubmed: 33876772
pii: 2025522118
doi: 10.1073/pnas.2025522118
pmc: PMC8053921
pii:
doi:
Substances chimiques
Eif4ebp2 protein, mouse
0
Eukaryotic Initiation Factors
0
Parvalbumins
0
Class I Phosphatidylinositol 3-Kinases
EC 2.7.1.137
Pik3ca protein, mouse
EC 2.7.1.137
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : FDN-148423
Pays : Canada
Organisme : CIHR
ID : PJT-162412
Pays : Canada
Organisme : CIHR
ID : MOP130328
Pays : Canada
Organisme : CIHR
ID : PJT-153311
Pays : Canada
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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