National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2020 Etiology and Prevention Working Group Report.

Chronic Disease Consensus Graft vs Host Disease / prevention & control Humans National Institutes of Health (U.S.) Recurrence United States

Journal

Transplantation and cellular therapy
ISSN: 2666-6367
Titre abrégé: Transplant Cell Ther
Pays: United States
ID NLM: 101774629

Informations de publication

Date de publication:
06 2021
Historique:
received: 25 02 2021
accepted: 26 02 2021
pubmed: 21 4 2021
medline: 3 7 2021
entrez: 20 4 2021
Statut: ppublish

Résumé

Preventing chronic graft-versus-host disease (GVHD) remains challenging because the unique cellular and molecular pathways that incite chronic GVHD are poorly understood. One major point of intervention for potential prevention of chronic GVHD occurs at the time of transplantation when acute donor anti-recipient immune responses first set the events in motion that result in chronic GVHD. After transplantation, additional insults causing tissue injury can incite aberrant immune responses and loss of tolerance, further contributing to chronic GVHD. Points of intervention are actively being identified so that chronic GVHD initiation pathways can be targeted without affecting immune function. The major objective in the field is to continue basic studies and to translate what is learned about etiopathology to develop targeted prevention strategies that decrease the risk of morbid chronic GVHD without increasing the risks of cancer relapse or infection. Development of strategies to predict the risk of developing debilitating or deadly chronic GVHD is a high research priority. This working group recommends further interrogation into the mechanisms underpinning chronic GVHD development, and we highlight considerations for future trial design in prevention trials.

Identifiants

DOI: 10.1016/j.jtct.2021.02.035 PMID: 33877965 PMC: PMC8217141
pubmed: 33877965
pii: S2666-6367(21)00742-9
doi: 10.1016/j.jtct.2021.02.035
pmc: PMC8217141
mid: NIHMS1680902
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

452-466

Subventions

Organisme : NCI NIH HHS
ID : P01 CA142106
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL129061
Pays : United States

Informations de copyright

Copyright © 2021 The American Society for Transplantation and Cellular Therapy. All rights reserved.

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Auteurs

Kirsten M Williams (KM)

Division of Blood and Marrow Transplantation, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia.

Yoshihiro Inamoto (Y)

Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.

Annie Im (A)

Division of Hematology Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.

Betty Hamilton (B)

Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.

John Koreth (J)

Dana-Farber Cancer Institute, Division of Hematologic Malignancies, Harvard Medical School, Boston, Massachusetts.

Mukta Arora (M)

Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota.

Iskra Pusic (I)

BMT and Leukemia Section, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri.

Jacqueline W Mays (JW)

National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland.

Paul A Carpenter (PA)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Leo Luznik (L)

Division of Hematologic Malignancies, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Pavan Reddy (P)

Divsion of Hematology and Oncology, University of Michigan Rogel Cancer Center, Ann Arbor, Michigan.

Jerome Ritz (J)

Dana-Farber Cancer Institute, Division of Hematologic Malignancies, Harvard Medical School, Boston, Massachusetts.

Hildegard Greinix (H)

Clinical Division of Hematology, Medical University of Graz, Graz, Austria.

Sophie Paczesny (S)

Department of Microbiology and Immunology and Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina.

Bruce R Blazar (BR)

Division of Pediatric Blood and Marrow Transplantation & Cellular Therapy, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

Joseph Pidala (J)

Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.

Corey Cutler (C)

Dana-Farber Cancer Institute, Division of Hematologic Malignancies, Harvard Medical School, Boston, Massachusetts.

Daniel Wolff (D)

Department of Internal Medicine III, University Hospital of Regensburg, Regensburg, Germany.

Kirk R Schultz (KR)

Pediatric Oncology, Hematology, and Bone Marrow Transplant, BC Children's Hospital, Vancouver, British Columbia, Canada.

Steven Z Pavletic (SZ)

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Stephanie J Lee (SJ)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, University of Washington, Seattle, Washington.

Paul J Martin (PJ)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, University of Washington, Seattle, Washington.

Gerard Socie (G)

Hematology Transplantation, Saint Louis Hospital, AP-HP, and University of Paris, INSERM U976, Paris, France. Electronic address: Gerard.socie@aphp.fr.

Stefanie Sarantopoulos (S)

Division of Hematological Malignancies and Cellular Therapy, Department of Medicine, Duke Cancer Institute, Durham, North Carolina. Electronic address: Stefanie.sarantopoulos@duke.edu.

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