Microtubule acetylation: A reading key to neural physiology and degeneration.
Acetylation
Glia
Microtubule
Neurodegeneration
Parkinson’s disease
Tubulin
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
11 06 2021
11 06 2021
Historique:
received:
27
12
2020
revised:
11
04
2021
accepted:
12
04
2021
pubmed:
21
4
2021
medline:
15
12
2021
entrez:
20
4
2021
Statut:
ppublish
Résumé
Neurons are the perfect example of cells where microtubules are essential to achieve an extraordinary degree of morphological and functional complexity. Different tubulin isoforms and associated post-translational modifications are the basis to establish the diversity in biochemical and biophysical properties of microtubules including their stability and the control of intracellular transport. Acetylation is one of the key tubulin modifications and it can influence important structural, mechanical and biological traits of the microtubule network. Here, we present the emerging evidence for the essential role of microtubule acetylation in the control of neuronal and glial function in healthy and degenerative conditions. In particular, we discuss the pathogenic role of tubulin acetylation in neurodegenerative disorders and focus on Parkinson's disease. We also provide a critical analysis about the possibility to target tubulin acetylation as a novel therapeutic intervention for neuroprotective strategies.
Identifiants
pubmed: 33878428
pii: S0304-3940(21)00278-0
doi: 10.1016/j.neulet.2021.135900
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
135900Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.