Natural variation in Caenorhabditis elegans responses to the anthelmintic emodepside.

Animals Anthelmintics / pharmacology Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / metabolism Depsipeptides Large-Conductance Calcium-Activated Potassium Channels
Anthelmintics C. elegans Emodepside Hormetic effect Natural variation

Journal

International journal for parasitology. Drugs and drug resistance
ISSN: 2211-3207
Titre abrégé: Int J Parasitol Drugs Drug Resist
Pays: Netherlands
ID NLM: 101576715

Informations de publication

Date de publication:
08 2021
Historique:
received: 18 01 2021
revised: 01 04 2021
accepted: 06 04 2021
pubmed: 21 4 2021
medline: 12 10 2021
entrez: 20 4 2021
Statut: ppublish

Résumé

Treatment of parasitic nematode infections depends primarily on the use of anthelmintics. However, this drug arsenal is limited, and resistance against most anthelmintics is widespread. Emodepside is a new anthelmintic drug effective against gastrointestinal and filarial nematodes. Nematodes that are resistant to other anthelmintic drug classes are susceptible to emodepside, indicating that the emodepside mode of action is distinct from previous anthelmintics. The laboratory-adapted Caenorhabditis elegans strain N2 is sensitive to emodepside, and genetic selection and in vitro experiments implicated slo-1, a large K

Identifiants

DOI: 10.1016/j.ijpddr.2021.04.001 PMID: 33878514 PMC: PMC8079822
pubmed: 33878514
pii: S2211-3207(21)00015-4
doi: 10.1016/j.ijpddr.2021.04.001
pmc: PMC8079822
pii:
doi:

Substances chimiques

Anthelmintics 0
Caenorhabditis elegans Proteins 0
Depsipeptides 0
Large-Conductance Calcium-Activated Potassium Channels 0
slo-1 protein, C elegans 0
emodepside YZ647Y5GC9

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-8

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI153088
Pays : United States

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Auteurs

Janneke Wit (J)

Molecular Biosciences, Northwestern University, Evanston, IL, 60208, USA.

Briana C Rodriguez (BC)

Molecular Biosciences, Northwestern University, Evanston, IL, 60208, USA.

Erik C Andersen (EC)

Molecular Biosciences, Northwestern University, Evanston, IL, 60208, USA. Electronic address: erik.andersen@northwestern.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Natural variation in Caenorhabditis elegans...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Anthelminthiques › Natural variation in Caenorhabditis elegans...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › Natural variation in Caenorhabditis elegans...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Protéines de Caenorhabditis elegans › Natural variation in Caenorhabditis elegans...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Depsipeptides › Natural variation in Caenorhabditis elegans...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques calcium-dépendants › Canaux potassiques calcium-dépendants de grande conductance › Natural variation in Caenorhabditis elegans...