Expression of
Adaptor Proteins, Signal Transducing
/ genetics
Adult
Biomarkers, Tumor
Breast Neoplasms
/ genetics
Calcium-Binding Proteins
/ genetics
Estrogen Receptor alpha
/ genetics
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Iran
Middle Aged
Prognosis
Proto-Oncogene Proteins c-bcl-2
/ genetics
BLC2
ER
IGFR1
Multigene model
SCUBE2
Journal
Archives of Iranian medicine
ISSN: 1735-3947
Titre abrégé: Arch Iran Med
Pays: Iran
ID NLM: 100889644
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
received:
31
05
2020
accepted:
19
10
2020
entrez:
21
4
2021
pubmed:
22
4
2021
medline:
16
11
2021
Statut:
epublish
Résumé
The study aimed at evaluating steroid biomarker genes ( The current study was conducted on 246 breast tissue samples. The expression levels of these genes and their relationships with clinicopathologic aspects and treatment response were evaluated. Based on immunohistochemistry (IHC) results, 12% of the ER negative patients expressed ERα. Comparing the effects of ERα and coexpression of Many studies suggest that PGR alone is not enough for the functional evaluation of ERα. Evaluation of the progesterone receptor expression as well as other genes such as
Sections du résumé
BACKGROUND
The study aimed at evaluating steroid biomarker genes (
METHODS
The current study was conducted on 246 breast tissue samples. The expression levels of these genes and their relationships with clinicopathologic aspects and treatment response were evaluated.
RESULTS
Based on immunohistochemistry (IHC) results, 12% of the ER negative patients expressed ERα. Comparing the effects of ERα and coexpression of
CONCLUSION
Many studies suggest that PGR alone is not enough for the functional evaluation of ERα. Evaluation of the progesterone receptor expression as well as other genes such as
Identifiants
pubmed: 33878879
doi: 10.34172/aim.2021.32
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
BCL2 protein, human
0
Biomarkers, Tumor
0
Calcium-Binding Proteins
0
ESR1 protein, human
0
Estrogen Receptor alpha
0
Proto-Oncogene Proteins c-bcl-2
0
SCUBE2 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
209-217Informations de copyright
© 2021 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.