White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study.
Journal
Journal of neurodevelopmental disorders
ISSN: 1866-1955
Titre abrégé: J Neurodev Disord
Pays: England
ID NLM: 101483832
Informations de publication
Date de publication:
20 04 2021
20 04 2021
Historique:
received:
10
02
2021
accepted:
08
04
2021
entrez:
21
4
2021
pubmed:
22
4
2021
medline:
27
8
2021
Statut:
epublish
Résumé
Nearly all persons with Down syndrome will show pathology of Alzheimer's disease in their 40s. There is a critical need for studies to identify early biomarkers of these various pathological changes of Alzheimer's disease in the Down syndrome population and understand the relationship of these biomarkers to cognitive symptoms in order to inform clinical trials. Although Alzheimer's disease is often considered a disease of gray matter, white matter degeneration has been documented during the preclinical stage of Alzheimer's disease. The current study examined the association between diffusion tensor imaging (DTI) measures of white matter microstructure and episodic memory performance in 52 adults with Down syndrome. Seventy (N = 70) participants (M = 40.13, SD = 7.77 years) received baseline scans as part of the Neurodegeneration in Aging Down Syndrome (NiAD) study at two imaging facilities (36 at the University of Wisconsin-Madison [UW-Madison] and 34 at the University of Pittsburgh Medical Center [UPMC]). All participants had genetically confirmed trisomy 21. Fifty-two (N = 52) participants remained after QC. The DTI measures, fractional anisotropy (FA) and mean diffusivity (MD), were calculated for each participant. A combined measure of episodic memory was generated by summing the z-scores of (1) Free and Cued Recall test and (2) Rivermead Behavioural Memory Test for Children Picture Recognition. The DTI data were projected onto a population-derived FA skeleton and tract-based spatial statistics analysis was conducted using the FSL tool PALM to calculate Pearson's r values between FA and MD with episodic memory. A positive correlation of episodic memory with FA and a negative correlation of episodic memory and MD in the major association white matter tracts were observed. Results were significant (p < 0.05) after correction for chronological age, imaging site, and premorbid cognitive ability. These findings suggest that white matter degeneration may be implicated in early episodic memory declines prior to the onset of dementia in adults with Down syndrome. Further, our findings suggest a coupling of episodic memory and white matter microstructure independent of chronological age.
Sections du résumé
BACKGROUND
Nearly all persons with Down syndrome will show pathology of Alzheimer's disease in their 40s. There is a critical need for studies to identify early biomarkers of these various pathological changes of Alzheimer's disease in the Down syndrome population and understand the relationship of these biomarkers to cognitive symptoms in order to inform clinical trials. Although Alzheimer's disease is often considered a disease of gray matter, white matter degeneration has been documented during the preclinical stage of Alzheimer's disease. The current study examined the association between diffusion tensor imaging (DTI) measures of white matter microstructure and episodic memory performance in 52 adults with Down syndrome.
METHODS
Seventy (N = 70) participants (M = 40.13, SD = 7.77 years) received baseline scans as part of the Neurodegeneration in Aging Down Syndrome (NiAD) study at two imaging facilities (36 at the University of Wisconsin-Madison [UW-Madison] and 34 at the University of Pittsburgh Medical Center [UPMC]). All participants had genetically confirmed trisomy 21. Fifty-two (N = 52) participants remained after QC. The DTI measures, fractional anisotropy (FA) and mean diffusivity (MD), were calculated for each participant. A combined measure of episodic memory was generated by summing the z-scores of (1) Free and Cued Recall test and (2) Rivermead Behavioural Memory Test for Children Picture Recognition. The DTI data were projected onto a population-derived FA skeleton and tract-based spatial statistics analysis was conducted using the FSL tool PALM to calculate Pearson's r values between FA and MD with episodic memory.
RESULTS
A positive correlation of episodic memory with FA and a negative correlation of episodic memory and MD in the major association white matter tracts were observed. Results were significant (p < 0.05) after correction for chronological age, imaging site, and premorbid cognitive ability.
CONCLUSION
These findings suggest that white matter degeneration may be implicated in early episodic memory declines prior to the onset of dementia in adults with Down syndrome. Further, our findings suggest a coupling of episodic memory and white matter microstructure independent of chronological age.
Identifiants
pubmed: 33879062
doi: 10.1186/s11689-021-09366-1
pii: 10.1186/s11689-021-09366-1
pmc: PMC8059162
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
17Subventions
Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Organisme : NIH HHS
ID : T32CA009206
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009206
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG031110
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090256
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062715
Pays : United States
Références
Neuroradiology. 2009 Nov;51(11):773-9
pubmed: 19603156
Neuroimage. 2009 Jan 1;44(1):83-98
pubmed: 18501637
Neuroimage Clin. 2015 Jan 27;7:482-92
pubmed: 25685715
Magn Reson Med. 2005 May;53(5):1088-95
pubmed: 15844157
Front Aging Neurosci. 2020 Aug 14;12:218
pubmed: 32922282
Neurol Sci. 2017 Jan;38(1):115-122
pubmed: 27672033
J Magn Reson B. 1996 Jun;111(3):209-19
pubmed: 8661285
Brain. 2014 Sep;137(Pt 9):2556-63
pubmed: 24993958
J Alzheimers Dis. 2015;44(2):585-98
pubmed: 25318544
Magn Reson Med. 2016 Nov;76(5):1574-1581
pubmed: 26745823
Neuroimage. 2016 Jan 15;125:1063-1078
pubmed: 26481672
Front Aging Neurosci. 2019 Jan 09;10:436
pubmed: 30687081
Neurotherapeutics. 2007 Jul;4(3):316-29
pubmed: 17599699
Neurobiol Aging. 2017 May;53:11-19
pubmed: 28192686
Alzheimers Dement. 2016 May;12(5):538-45
pubmed: 26362596
Neuroimage. 2014 May 15;92:381-97
pubmed: 24530839
PLoS One. 2012;7(6):e37720
pubmed: 22701578
J Clin Neuropsychol. 1984 Nov;6(4):433-40
pubmed: 6501581
Front Aging Neurosci. 2014 Oct 02;6:266
pubmed: 25324775
Neuroimage. 2016 Nov 15;142:394-406
pubmed: 27523449
JAMA Neurol. 2020 Feb 1;77(2):262-264
pubmed: 31657825
Biophys J. 1994 Jan;66(1):259-67
pubmed: 8130344
Alzheimers Res Ther. 2011 Jan 06;3(1):1
pubmed: 21211070
Res Dev Disabil. 2014 Feb;35(2):429-38
pubmed: 24361811
Alzheimers Dement. 2013 Sep;9(5):519-28
pubmed: 23245561
Neurobiol Aging. 2002 May-Jun;23(3):433-41
pubmed: 11959406
Front Hum Neurosci. 2012 Mar 16;6:56
pubmed: 22438841
Neurobiol Aging. 2014 Jul;35(7):1562-9
pubmed: 24582640
Alzheimers Dement. 2016 Apr;12(4):380-90
pubmed: 26079411
Neuroimage. 2006 Jul 15;31(4):1487-505
pubmed: 16624579
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
J Intellect Disabil Res. 2014 Jan;58(1):61-70
pubmed: 23902161
Nat Rev Dis Primers. 2020 Feb 6;6(1):9
pubmed: 32029743
Neuroimage. 2019 Nov 15;202:116137
pubmed: 31473352
Alzheimers Dement (Amst). 2020 Sep 13;12(1):e12096
pubmed: 32995465
PLoS One. 2011;6(6):e21745
pubmed: 21738785
Front Neuroinform. 2014 Feb 21;8:8
pubmed: 24600385
J Ment Defic Res. 1989 Jun;33 ( Pt 3):193-210
pubmed: 2526879
Neuroimage Clin. 2014 Feb 19;4:604-14
pubmed: 24936411
J Neurosci. 2011 Sep 14;31(37):13236-45
pubmed: 21917806
Neuroimage. 2004;23 Suppl 1:S208-19
pubmed: 15501092
Neuroradiology. 2018 Dec;60(12):1335-1341
pubmed: 30264168
Neuroimage Clin. 2016 Dec 16;13:330-338
pubmed: 28066707
Br J Clin Psychol. 1991 May;30(2):161-8
pubmed: 2059748
Neuroimage. 2011 Feb 1;54(3):2033-44
pubmed: 20851191
Neurology. 2012 Feb 7;78(6):379-86
pubmed: 22238414
Neuroimage. 2016 Nov 1;141:556-572
pubmed: 27393418
Neuroimage Clin. 2017 Nov 06;17:263-271
pubmed: 29159043
J Comput Assist Tomogr. 2020 May/Jun;44(3):393-398
pubmed: 32217895
Magn Reson Med. 1996 Dec;36(6):893-906
pubmed: 8946355
Neurobiol Aging. 2017 Oct;58:68-76
pubmed: 28715661
Neuroimage. 2008 Nov 15;43(3):447-57
pubmed: 18692144
AJR Am J Roentgenol. 2010 Dec;195(6):W456-62
pubmed: 21098179
J Geriatr Psychiatry Neurol. 2010 Dec;23(4):213-27
pubmed: 21045163