Association of Oophorectomy and Fat and Lean Body Mass: Evidence from a Population-Based Sample of U.S. Women.
Absorptiometry, Photon
Adiposity
Adult
Age Factors
Aged
Body Mass Index
Cross-Sectional Studies
Female
Humans
Hysterectomy
/ methods
Leiomyoma
/ surgery
Middle Aged
Nutrition Surveys
Ovarian Neoplasms
/ prevention & control
Ovariectomy
/ methods
Prophylactic Surgical Procedures
/ statistics & numerical data
Risk Factors
United States
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
06
01
2021
revised:
09
03
2021
accepted:
13
04
2021
pubmed:
22
4
2021
medline:
22
2
2022
entrez:
21
4
2021
Statut:
ppublish
Résumé
Bilateral oophorectomy during a nonmalignant hysterectomy is frequently performed for ovarian cancer prevention in premenopausal women. Oophorectomy before menopause leads to an abrupt decline in ovarian hormones that could adversely affect body composition. We examined the relationship between oophorectomy and whole-body composition. Our study population included cancer-free women 35 to 70 years old from the 1999-2006 National Health and Nutrition Examination Survey, a representative sample of the U.S. A total of 4,209 women with dual-energy x-ray absorptiometry scans were identified, including 445 with hysterectomy, 552 with hysterectomy and oophorectomy, and 3,212 with no surgery. Linear regression was used to estimate the difference in total and regional (trunk, arms, and legs) fat and lean body mass by surgery status. In multivariable models, hysterectomy with and without oophorectomy was associated with higher total fat mass [mean percent difference (β); β Hysterectomy with oophorectomy, particularly in young women, may be associated with systemic changes in fat and lean body mass irrespective of BMI. Our results support prospective evaluation of body composition in women undergoing hysterectomy with oophorectomy at a young age.
Sections du résumé
BACKGROUND
Bilateral oophorectomy during a nonmalignant hysterectomy is frequently performed for ovarian cancer prevention in premenopausal women. Oophorectomy before menopause leads to an abrupt decline in ovarian hormones that could adversely affect body composition. We examined the relationship between oophorectomy and whole-body composition.
METHODS
Our study population included cancer-free women 35 to 70 years old from the 1999-2006 National Health and Nutrition Examination Survey, a representative sample of the U.S.
POPULATION
A total of 4,209 women with dual-energy x-ray absorptiometry scans were identified, including 445 with hysterectomy, 552 with hysterectomy and oophorectomy, and 3,212 with no surgery. Linear regression was used to estimate the difference in total and regional (trunk, arms, and legs) fat and lean body mass by surgery status.
RESULTS
In multivariable models, hysterectomy with and without oophorectomy was associated with higher total fat mass [mean percent difference (β); β
CONCLUSIONS
Hysterectomy with oophorectomy, particularly in young women, may be associated with systemic changes in fat and lean body mass irrespective of BMI.
IMPACT
Our results support prospective evaluation of body composition in women undergoing hysterectomy with oophorectomy at a young age.
Identifiants
pubmed: 33879451
pii: 1055-9965.EPI-20-1849
doi: 10.1158/1055-9965.EPI-20-1849
pmc: PMC8258842
mid: NIHMS1696336
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1424-1432Subventions
Organisme : NCI NIH HHS
ID : P30 CA006973
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009314
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
Références
J Neurosci. 2006 Oct 11;26(41):10332-48
pubmed: 17035515
J Am Geriatr Soc. 2002 May;50(5):889-96
pubmed: 12028177
Sci Rep. 2019 Mar 29;9(1):5379
pubmed: 30926844
Am J Obstet Gynecol. 2018 Apr;218(4):425.e1-425.e18
pubmed: 29288067
Obstet Gynecol. 2009 Jun;113(6):1259-1267
pubmed: 19461420
Menopause. 2009 Jan-Feb;16(1):15-23
pubmed: 19034050
JAMA. 2010 Sep 1;304(9):967-75
pubmed: 20810374
J Am Heart Assoc. 2016 Jul 28;5(8):
pubmed: 27468929
Am J Epidemiol. 2006 Nov 15;164(10):1003-11
pubmed: 16928728
Int J Obes (Lond). 2013 Jun;37(6):809-13
pubmed: 23007036
Menopause. 2011 Jan;18(1):44-52
pubmed: 20689466
Endocrinology. 2009 May;150(5):2161-8
pubmed: 19179442
Obesity (Silver Spring). 2012 Jan;20(1):30-9
pubmed: 21760631
Life Sci. 1999;64(24):2299-306
pubmed: 10374920
Obstet Gynecol. 2013 Apr;121(4):717-726
pubmed: 23635670
JAMA Netw Open. 2019 Aug 2;2(8):e1910154
pubmed: 31461147
Maturitas. 2011 Apr;68(4):331-6
pubmed: 21353405
Am J Obstet Gynecol. 2015 Nov;213(5):716.e1-6
pubmed: 26032038
J Steroid Biochem Mol Biol. 2010 Oct;122(1-3):100-5
pubmed: 20298783
Am J Epidemiol. 1987 Aug;126(2):319-25
pubmed: 3605058
Gynecol Oncol. 2013 Jun;129(3):559-64
pubmed: 23428461
Physiol Behav. 1987;39(3):361-5
pubmed: 3575476
Brain Res. 2011 Mar 16;1379:188-98
pubmed: 20965156
Climacteric. 2006 Aug;9(4):283-9
pubmed: 16857658
Age Ageing. 2012 Sep;41(5):677-81
pubmed: 22820447
J Musculoskelet Neuronal Interact. 2009 Oct-Dec;9(4):186-97
pubmed: 19949277
Int J Obes (Lond). 2008 Jun;32(6):949-58
pubmed: 18332882
Am J Epidemiol. 1998 Apr 15;147(8):755-63
pubmed: 9554417
JAMA Oncol. 2019 Feb 1;5(2):155-163
pubmed: 30520976
Endocr Rev. 2002 Feb;23(1):90-119
pubmed: 11844745
J Investig Med. 2018 Jun;66(5):1-9
pubmed: 29581385
J Clin Epidemiol. 1990;43(2):181-7
pubmed: 2303847
J Immunol. 2009 Jul 15;183(2):1393-402
pubmed: 19553526
Cancer Prev Res (Phila). 2012 Jun;5(6):847-54
pubmed: 22556202
Biochem Pharmacol. 2009 Oct 15;78(8):1001-7
pubmed: 19501056
Mayo Clin Proc. 2016 Nov;91(11):1577-1589
pubmed: 27693001
Eur Heart J. 2019 Sep 7;40(34):2849-2855
pubmed: 31256194
Maturitas. 2002 Mar 25;41(3):187-92
pubmed: 11886764
J Clin Endocrinol Metab. 2007 Mar;92(3):895-901
pubmed: 17192296
Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5134-8
pubmed: 2052592
Obstet Gynecol. 2013 Apr;121(4):709-716
pubmed: 23635669
Nutr J. 2009 Feb 17;8:11
pubmed: 19220919
Menopause. 2009 Mar-Apr;16(2):279-85
pubmed: 18971792
Clin Physiol Funct Imaging. 2015 Mar;35(2):81-97
pubmed: 24735332
BMJ. 2008 Jul 01;337:a439
pubmed: 18595904
Obstet Gynecol. 2011 Dec;118(6):1271-1279
pubmed: 22067716
Eur J Clin Nutr. 2014 Sep;68(9):1001-7
pubmed: 24961545
N Engl J Med. 1987 Apr 30;316(18):1105-10
pubmed: 3574358
J Clin Endocrinol Metab. 2003 Jun;88(6):2404-11
pubmed: 12788835
Obstet Gynecol. 2009 May;113(5):1027-1037
pubmed: 19384117
Am J Epidemiol. 2010 Jun 1;171(11):1203-13
pubmed: 20427327
J Womens Health (Larchmt). 2009 May;18(5):699-708
pubmed: 19445617
Neurology. 2007 Sep 11;69(11):1074-83
pubmed: 17761551
Maturitas. 2007 Nov 20;58(3):296-307
pubmed: 17945444