Single-cell multi-omics analysis of the immune response in COVID-19.
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
15
01
2021
accepted:
23
03
2021
pubmed:
22
4
2021
medline:
25
5
2021
entrez:
21
4
2021
Statut:
ppublish
Résumé
Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19. We identified expansion of nonclassical monocytes expressing complement transcripts (CD16
Identifiants
pubmed: 33879890
doi: 10.1038/s41591-021-01329-2
pii: 10.1038/s41591-021-01329-2
pmc: PMC8121667
doi:
Substances chimiques
Proteome
0
Receptors, Antigen, B-Cell
0
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
904-916Subventions
Organisme : Wellcome Trust
ID : 207556/Z/17/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204721/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K017047/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S005579/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R015635/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17230
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S035842/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/W014556/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P008801/1
Pays : United Kingdom
Investigateurs
Stephen Baker
(S)
John R Bradley
(JR)
Gordon Dougan
(G)
Ian G Goodfellow
(IG)
Ravindra K Gupta
(RK)
Christoph Hess
(C)
Nathalie Kingston
(N)
Paul J Lehner
(PJ)
Nicholas J Matheson
(NJ)
Willem H Owehand
(WH)
Caroline Saunders
(C)
Kenneth G C Smith
(KGC)
Charlotte Summers
(C)
James E D Thaventhiran
(JED)
Mark Toshner
(M)
Michael P Weekes
(MP)
Ashlea Bucke
(A)
Jo Calder
(J)
Laura Canna
(L)
Jason Domingo
(J)
Anne Elmer
(A)
Stewart Fuller
(S)
Julie Harris
(J)
Sarah Hewitt
(S)
Jane Kennet
(J)
Sherly Jose
(S)
Jenny Kourampa
(J)
Anne Meadows
(A)
Criona O'Brien
(C)
Jane Price
(J)
Cherry Publico
(C)
Rebecca Rastall
(R)
Carla Ribeiro
(C)
Jane Rowlands
(J)
Valentina Ruffolo
(V)
Hugo Tordesillas
(H)
Ben Bullman
(B)
Benjamin J Dunmore
(BJ)
Stuart Fawke
(S)
Stefan Gräf
(S)
Josh Hodgson
(J)
Christopher Huang
(C)
Kelvin Hunter
(K)
Emma Jones
(E)
Ekaterina Legchenko
(E)
Cecilia Matara
(C)
Jennifer Martin
(J)
Ciara O'Donnell
(C)
Linda Pointon
(L)
Nicole Pond
(N)
Joy Shih
(J)
Rachel Sutcliffe
(R)
Tobias Tilly
(T)
Carmen Treacy
(C)
Zhen Tong
(Z)
Jennifer Wood
(J)
Marta Wylot
(M)
Ariana Betancourt
(A)
Georgie Bower
(G)
Aloka De Sa
(A)
Madeline Epping
(M)
Oisin Huhn
(O)
Sarah Jackson
(S)
Isobel Jarvis
(I)
Jimmy Marsden
(J)
Francesca Nice
(F)
Georgina Okecha
(G)
Ommar Omarjee
(O)
Marianne Perera
(M)
Nathan Richoz
(N)
Rahul Sharma
(R)
Lori Turner
(L)
Eckart M D D De Bie
(EMDD)
Katherine Bunclark
(K)
Masa Josipovic
(M)
Michael Mackay
(M)
Alice Michael
(A)
Sabrina Rossi
(S)
Mayurun Selvan
(M)
Sarah Spencer
(S)
Cissy Yong
(C)
Ali Ansaripour
(A)
Lucy Mwaura
(L)
Caroline Patterson
(C)
Gary Polwarth
(G)
Petra Polgarova
(P)
Giovanni di Stefano
(GD)
John Allison
(J)
Helen Butcher
(H)
Daniela Caputo
(D)
Debbie Clapham-Riley
(D)
Eleanor Dewhurst
(E)
Anita Furlong
(A)
Barbara Graves
(B)
Jennifer Gray
(J)
Tasmin Ivers
(T)
Mary Kasanicki
(M)
Emma Le Gresley
(EL)
Rachel Linger
(R)
Sarah Meloy
(S)
Francesca Muldoon
(F)
Nigel Ovington
(N)
Sofia Papadia
(S)
Isabel Phelan
(I)
Hannah Stark
(H)
Kathleen E Stirrups
(KE)
Paul Townsend
(P)
Neil Walker
(N)
Jennifer Webster
(J)
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