Bioactive Compounds and Traditional Herbal Medicine: Promising Approaches for the Treatment of Dementia.
Alzheimer’s disease
bioactive compounds
cognitive impairment
dementia
medicinal plants
vascular dementia
Journal
Degenerative neurological and neuromuscular disease
ISSN: 1179-9900
Titre abrégé: Degener Neurol Neuromuscul Dis
Pays: New Zealand
ID NLM: 101587980
Informations de publication
Date de publication:
2021
2021
Historique:
received:
06
01
2021
accepted:
23
03
2021
entrez:
21
4
2021
pubmed:
22
4
2021
medline:
22
4
2021
Statut:
epublish
Résumé
Dementia is a term that encompasses a group of clinical symptoms affecting memory, thinking and social abilities, characterized by progressive impairment of memory performance and cognitive functions. There are several factors involved in the pathogenesis and progression of dementia, such as old age, brain ischemia, toxin exposure, and oxidative stress. There are extensive similarities between dementia and Alzheimer's disease (AD) either in clinical manifestations or experimental animal models. AD is the most dominant form of dementia, characterized by the accumulation of beta-amyloid protein and cholinergic neurotransmission deficits in the brain. Currently available medications for the treatment of dementia, such as choline esterase inhibitors, N-methyl-D-aspartate (NMDA) antagonists (memantine), have short-term efficacy and only relieve symptoms rather than targeting the main underlying pathogenesis. Several animal studies and clinical trials are being conducted to provide a rational approach to these medicinal plants in the prevention or treatment of memory deficits. This review highlights the potential effects of medicinal plants and their derived lead molecules, and explains the related mechanisms and effects reviewed from published literature as major thrust aspects and hopeful strategies in the prevention or treatment of dementia.
Identifiants
pubmed: 33880073
doi: 10.2147/DNND.S299589
pii: 299589
pmc: PMC8051957
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1-14Informations de copyright
© 2021 Alzobaidi et al.
Déclaration de conflit d'intérêts
The authors have declared no conflicts of interest for this work.
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