The aging endothelium.
age-related disease
aging
endothelium
senescence
vascular dysfunction
Journal
Vascular biology (Bristol, England)
ISSN: 2516-5658
Titre abrégé: Vasc Biol
Pays: England
ID NLM: 101763329
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
12
2020
accepted:
12
01
2021
entrez:
21
4
2021
pubmed:
22
4
2021
medline:
22
4
2021
Statut:
epublish
Résumé
Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases. Endothelial senescence can result in systemic metabolic changes, implicating senescence in chronic diseases such as diabetes, obesity and atherosclerosis. Senolytics, drugs that eliminate senescent cells, afford new therapeutic strategies for control of these chronic diseases.
Identifiants
pubmed: 33880430
doi: 10.1530/VB-20-0013
pii: VB-20-0013
pmc: PMC8052565
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
R35-R47Informations de copyright
© 2021 The authors.
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