Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis.
Animals
Cyclic AMP Response Element-Binding Protein
/ physiology
Female
Fibroblast Growth Factors
/ physiology
Glucagon
/ metabolism
Gluconeogenesis
/ physiology
Hypoglycemia
/ prevention & control
Hypothalamus
/ metabolism
Liver
/ metabolism
Male
Mice
Mice, Inbred C57BL
Neurons
/ physiology
Sympathetic Nervous System
/ physiology
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
04
11
2020
accepted:
03
04
2021
pubmed:
23
4
2021
medline:
18
9
2021
entrez:
22
4
2021
Statut:
ppublish
Résumé
The counterregulatory response to hypoglycemia is an essential survival function. It is controlled by an integrated network of glucose-responsive neurons, which trigger endogenous glucose production to restore normoglycemia. The complexity of this glucoregulatory network is, however, only partly characterized. In a genetic screen of a panel of recombinant inbred mice we previously identified
Identifiants
pubmed: 33883213
pii: db20-1121
doi: 10.2337/db20-1121
pmc: PMC8336003
doi:
Substances chimiques
Creb1 protein, mouse
0
Cyclic AMP Response Element-Binding Protein
0
fibroblast growth factor 15, mouse
0
Fibroblast Growth Factors
62031-54-3
Glucagon
9007-92-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1443-1457Informations de copyright
© 2021 by the American Diabetes Association.
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