Risk stratification of adults with congenital heart disease during the COVID-19 pandemic: insights from a multinational survey among European experts.
COVID-19
/ diagnosis
Eisenmenger Complex
/ epidemiology
Europe
/ epidemiology
Fontan Procedure
/ statistics & numerical data
Global Burden of Disease
Heart Defects, Congenital
/ classification
Humans
Outcome Assessment, Health Care
/ methods
Prognosis
Pulmonary Arterial Hypertension
/ epidemiology
Risk Assessment
/ methods
Risk Factors
SARS-CoV-2
Societies, Medical
Surveys and Questionnaires
COVID-19
congenital
global burden of disease
heart defects
Journal
Open heart
ISSN: 2053-3624
Titre abrégé: Open Heart
Pays: England
ID NLM: 101631219
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
18
09
2020
revised:
09
03
2021
accepted:
22
03
2021
entrez:
22
4
2021
pubmed:
23
4
2021
medline:
8
5
2021
Statut:
ppublish
Résumé
Adults with congenital heart disease (ACHD) may be at a higher risk of a fatal outcome in case of COVID-19. Current risk stratification among these patients relies on personal experience and extrapolation from patients with acquired heart disease. We aimed to provide an expert view on risk stratification while awaiting results from observational studies. This study was an initiative of the EPOCH (European Collaboration for Prospective Outcome Research in Congenital Heart disease). Among nine European countries (Austria, Belgium, Denmark, France, Germany, Italy, the Netherlands, Spain and Switzerland), 24 experts from 23 tertiary ACHD centres participated in the survey. ACHD experts were asked to identify ACHD-specific COVID-19 risk factors from a list of potential outcome predictors and to estimate the risk of adverse COVID-19 outcomes in seven commonly seen patient scenarios. 82% of participants did not consider all ACHD patients at risk of COVID-19 related complications. There was a consensus on pulmonary arterial hypertension, Fontan physiology and cyanotic heart disease as risk factors for adverse outcomes. Among different ACHD scenarios, a patient with Eisenmenger syndrome was considered to be at the highest risk. There was a marked variability in risk estimation among the other potential outcome predictors and ACHD scenarios. Pulmonary arterial hypertension, Fontan palliation and cyanotic heart disease were widely considered as risk factors for poor outcome in COVID-19. However, there was a marked disparity in risk estimation for other clinical scenarios. We are in urgent need of outcome studies in ACHD suffering from COVID-19.
Identifiants
pubmed: 33883228
pii: openhrt-2020-001455
doi: 10.1136/openhrt-2020-001455
pmc: PMC8061557
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Werner Budts
(W)
Massimo Chessa
(M)
Julie De Backer
(J)
Gerhard Diller
(G)
Rocío García Orta
(RG)
María Elvira
(M)
Rodríguez-Monte Garrido-Lestache
(RM)
Elvira Ana González
(EA)
Pablo Meras
(P)
Berta Miranda
(B)
Marielle Morissens
(M)
Agnes Pasquet
(A)
Joaquin Rueda Soriano
(JR)
Annette Schophuus Jensen
(AS)
Oktay Tutare
(O)
Annemien van den Bosch
(AVD)
Heleen van der Zwaan
(HV)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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