Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injury.
long term oxygen therapy (LTOT)
oxidative stress
paediatric interstitial lung disease
paediatric lung disaese
Journal
Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
26
10
2020
revised:
29
03
2021
accepted:
02
04
2021
pubmed:
23
4
2021
medline:
3
2
2022
entrez:
22
4
2021
Statut:
ppublish
Résumé
Neonatal lung injury as a consequence of hyperoxia (HO) therapy and ventilator care contribute to the development of bronchopulmonary dysplasia (BPD). Increased expression and activity of lysyl oxidase (LOX), a key enzyme that cross-links collagen, was associated with increased sphingosine kinase 1 (SPHK1) in human BPD. We, therefore, examined closely the link between LOX and SPHK1 in BPD. The enzyme expression of SPHK1 and LOX were assessed in lung tissues of human BPD using immunohistochemistry and quantified (Halo). In vivo studies were based on Both SPHK1 and LOX expressions were increased in lungs of patients with BPD. Tracheal aspirates from patients with BPD had increased LOX, correlating with sphingosine-1-phosphate (S1P) levels. HO-induced increase of LOX in lungs were attenuated in both HO-induced SPHK1/S1P signalling axis plays a critical role in transcriptional regulation of LOX expression via SPNS2, S1P
Identifiants
pubmed: 33883249
pii: thoraxjnl-2020-216469
doi: 10.1136/thoraxjnl-2020-216469
pmc: PMC9115769
mid: NIHMS1799904
doi:
Substances chimiques
STAT3 Transcription Factor
0
STAT3 protein, human
0
Protein-Lysine 6-Oxidase
EC 1.4.3.13
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
sphingosine kinase
EC 2.7.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
47-57Subventions
Organisme : NICHD NIH HHS
ID : R01 HD090887
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL122700
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL148861
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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