Plasma Metabolic Profiling in Patients With Silicosis and Asbestosis.
Journal
Journal of occupational and environmental medicine
ISSN: 1536-5948
Titre abrégé: J Occup Environ Med
Pays: United States
ID NLM: 9504688
Informations de publication
Date de publication:
01 09 2021
01 09 2021
Historique:
pubmed:
23
4
2021
medline:
28
10
2021
entrez:
22
4
2021
Statut:
ppublish
Résumé
To explore the circulating metabolites and related pathways in silicosis and asbestosis exposure to different mineral dust. Plasma of 30 silicosis, 30 asbestosis, and 20 healthy controls was analyzed using liquid chromatography-mass spectrometry. Metabolic networks and the relevance of the identified metabolic derangements were explored. Compared with healthy controls, 37 and 39 dysregulated plasma metabolites were found in silicosis and asbestosis, respectively, of which the levels of 22 metabolites differed. Three major pathways were identified, among which arginine and proline metabolism was identified as the most closely related metabolic pathway. The types and quantities of up-regulated metabolites including lipids, amino acids, and carnitines differed between silicosis and asbestosis. Pathways inducing lung fibrosis were common to mineral dust exposure, while pathways related to oxidative stress and tumorigenesis differed between silicosis and asbestosis.
Identifiants
pubmed: 33883533
doi: 10.1097/JOM.0000000000002232
pii: 00043764-202109000-00008
doi:
Substances chimiques
Dust
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
787-793Informations de copyright
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Occupational and Environmental Medicine.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors report no conflicts of interest.
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