Circulating short and medium chain fatty acids are associated with normoalbuminuria in type 1 diabetes of long duration.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 04 2021
21 04 2021
Historique:
received:
15
10
2020
accepted:
30
03
2021
entrez:
22
4
2021
pubmed:
23
4
2021
medline:
16
11
2021
Statut:
epublish
Résumé
A substantial number of subjects with Type 1 Diabetes (T1D) of long duration never develop albuminuria or renal function impairment, yet the underlying protective mechanisms remain unknown. Therefore, our study included 308 Joslin Kidney Study subjects who had T1D of long duration (median: 24 years), maintained normal renal function and had either normoalbuminuria or a broad range of albuminuria within the 2 years preceding the metabolomic determinations. Serum samples were subjected to global metabolomic profiling. 352 metabolites were detected in at least 80% of the study population. In the logistic analyses adjusted for multiple testing (Bonferroni corrected α = 0.000028), we identified 38 metabolites associated with persistent normoalbuminuria independently from clinical covariates. Protective metabolites were enriched in Medium Chain Fatty Acids (MCFAs) and in Short Chain Fatty Acids (SCFAs) and particularly involved odd-numbered and dicarboxylate Fatty Acids. One quartile change of nonanoate, the top protective MCFA, was associated with high odds of having persistent normoalbuminuria (OR (95% CI) 0.14 (0.09, 0.23); p < 10
Identifiants
pubmed: 33883567
doi: 10.1038/s41598-021-87585-1
pii: 10.1038/s41598-021-87585-1
pmc: PMC8060327
doi:
Substances chimiques
Biomarkers
0
Fatty Acids
0
Fatty Acids, Volatile
0
pelargonic acid
97SEH7577T
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8592Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK036836
Pays : United States
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