Non-steroidal anti-inflammatory drugs and gabapentinoids for chronic lumbar pain: a Bayesian network meta-analysis of randomized controlled trials.

Anti-Inflammatory Agents, Non-Steroidal / therapeutic use Bayes Theorem Humans Low Back Pain / drug therapy Network Meta-Analysis Pharmaceutical Preparations Randomized Controlled Trials as Topic
NSAID Spine chronic gabapentinoids Level of evidence Level I of evidence, Bayesian network meta-analysis of RCTs low back pain

Journal

British medical bulletin
ISSN: 1471-8391
Titre abrégé: Br Med Bull
Pays: England
ID NLM: 0376542

Informations de publication

Date de publication:
10 06 2021
Historique:
received: 31 07 2020
revised: 27 01 2021
accepted: 31 01 2021
pubmed: 23 4 2021
medline: 26 10 2021
entrez: 22 4 2021
Statut: ppublish

Résumé

Several pharmacological therapies have been proposed for the management of chronic low back pain (LBP), but no consensus has been reached yet. Recent published literatures identified accessing PubMed, Google scholar, Embase and Scopus. Exploring effective conservative alternatives to the surgical intervention is of especial interest. The efficacy and safety of non-steroidal anti-inflammatory drugs and gabapentinoids for chronic LBP are debated. Several clinical studies showed controversial results, and the most effective and safe class of drugs has not yet been clarified. The effects of selective and non-selective NSAIDs and gabapentinoids in chronic LBP are probably over-estimated. The effect of behavioural changes, including exercise, should be explored, alone or in combination with drugs.

Identifiants

DOI: 10.1093/bmb/ldab003 PMID: 33884409
pubmed: 33884409
pii: 6244771
doi: 10.1093/bmb/ldab003
doi:

Substances chimiques

Anti-Inflammatory Agents, Non-Steroidal 0
Pharmaceutical Preparations 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

85-95

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Auteurs

Filippo Migliorini (F)

Department of Orthopaedics, University Clinic Aachen, RWTH Aachen University Clinic, Pauwelsstraße 30, 52074 Aachen, Germany.

Nicola Maffulli (N)

Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, Salerno, Italy.
School of Pharmacy and Bioengineering, Keele University School of Medicine, Thornburrow Drive, Stoke on Trent ST4 7QB, United Kingdom.
Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Centre for Sports and Exercise Medicine, Mile End Hospital, 275 Bancroft Road, London E1 4DG, United Kingdom.

Jörg Eschweiler (J)

Department of Orthopaedics, University Clinic Aachen, RWTH Aachen University Clinic, Pauwelsstraße 30, 52074 Aachen, Germany.

Markus Tingart (M)

Department of Orthopaedics, University Clinic Aachen, RWTH Aachen University Clinic, Pauwelsstraße 30, 52074 Aachen, Germany.

Alice Baroncini (A)

Department of Orthopaedics, University Clinic Aachen, RWTH Aachen University Clinic, Pauwelsstraße 30, 52074 Aachen, Germany.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antirhumatismaux › Anti-inflammatoires non stéroïdiens › Non-steroidal anti-inflammatory drugs and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Théorème de Bayes › Non-steroidal anti-inflammatory drugs and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Non-steroidal anti-inflammatory drugs and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Dorsalgie › Lombalgie › Non-steroidal anti-inflammatory drugs and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Méta-analyse comme sujet › Méta-analyse en réseau › Non-steroidal anti-inflammatory drugs and...
questionsmedicales.fr › Préparations pharmaceutiques › Non-steroidal anti-inflammatory drugs and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Non-steroidal anti-inflammatory drugs and...