The protective effects of hesperidin and curcumin on 5-fluorouracil-induced nephrotoxicity in mice.
Apoptosis
Curcumin
Hesperidin
Histopathology
Immunohistochemistry
Mice
Nephrotoxicity
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
23
12
2020
accepted:
12
04
2021
pubmed:
23
4
2021
medline:
27
8
2021
entrez:
22
4
2021
Statut:
ppublish
Résumé
Nephrotoxicity is a very important complication of 5-fluorouracil (5-FU)-treated cancer patients. Increased oxidative stress, kidney damage, and apoptosis play an important role in the pathogenesis of nephrotoxicity caused by 5-FU. In this study, protective effects of two natural compounds, hesperidin and curcumin, on experimentally induced kidney damage in mice with 5-FU were determined. Application of 5-FU resulted in severe histopathological changes and severe renal failure with increased serum urea and creatinine levels. Also, 5-FU-induced kidney damage, increased levels of malondialdehyde (MDA), decreased superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) activity, and glutathione (GSH) level have been demonstrated. Also, where 5-FU is in the concentration of caspase-3 and 8-OHdG immune-positive cells and therefore causes apoptosis and DNA damage in kidney tissue cells. However, especially high doses of hesperidin and curcumin treatment significantly improved 5-FU-induced oxidative stress/lipid peroxidation, apoptosis/DNA damage, and renal dysfunction. Based on these data, our results suggest that hesperidin and curcumin may be used as new and promising agents against 5-FU-induced nephrotoxicity.
Identifiants
pubmed: 33886055
doi: 10.1007/s11356-021-13969-5
pii: 10.1007/s11356-021-13969-5
doi:
Substances chimiques
Antioxidants
0
Malondialdehyde
4Y8F71G49Q
Hesperidin
E750O06Y6O
Superoxide Dismutase
EC 1.15.1.1
Glutathione
GAN16C9B8O
Curcumin
IT942ZTH98
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
47046-47055Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Abdel-Daim MM, Abdou RH (2015) Protective effects of diallyl sulfide and curcumin separately against thallium-induced toxicity in rats. Cell J 17:379–388
Abdel-Diam MM, Samak DH, El-Sayed YS, Aleya L, Alarifi S, Alkahtani S (2019) Curcumin and quercetin synergistically attenuate subacute diazinon-induced inflammation and oxidative neurohepatic damage, and acetylcholinesterase inhibition in albino rats. Environ Sci Pollut Res Int 26:3659–3665
doi: 10.1007/s11356-018-3907-9
Aebi H (1983) Catalase. In: Bergmeyer HU (ed) Methods in enzymatic analysis. Academic Press, New York, pp 276–286
Ahmad ST, Arjumand W, Nafees S, Seth A, Ali N, Rashid S, Sultana S (2012) Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation. Toxicol Lett 208:149–161
doi: 10.1016/j.toxlet.2011.10.023
Ammon HPT, Wahl MA (1991) Pharmacology of Curcuma longa. Planta Med 57:1–7
doi: 10.1055/s-2006-960004
Bosetti C, Rossi M, McLaughlin JK, Negri E, Talamini R, Lagiou P, Montella M, Ramazzotti V, Franceschi S, LaVecchia C (2007) Flavonoids and the risk of renal cell carcinoma. Cancer Epidemiol Biomark Prev 16:98–101
doi: 10.1158/1055-9965.EPI-06-0769
Cadet J (2016) Oxidative degradation pathways of cellular DNA: product formation and mechanistic insights. Free Radic Biol Med 75:S2
doi: 10.1016/j.freeradbiomed.2014.10.598
Cadet J, Douki T, Gasparutto D, Ravanat JL (2003) Oxidative damage to DNA: formation, measurement and biochemical features. Mutat Res Fund Mol M 531:5–23
doi: 10.1016/j.mrfmmm.2003.09.001
Carlberg I, Mannervik B (1975) Glutathione reductase levels in rat brain. J Biol Chem 250:5475–5480
doi: 10.1016/S0021-9258(19)41206-4
Chanet A, Milenkovic D, Manach C, Mazur A, Morand C (2012) Citrus flavanones: what is their role in cardiovascular protection? J Agric Food Chem 60:8809–8822
doi: 10.1021/jf300669s
Chang CT, Ho TY, Lin H, Liang JA, Huang HC, Li CC, Lo HY, Wu SL, Huang YF, Hsiang CY (2012) 5-Fluorouracil induced intestinal mucositis via nuclear factor-kB activation by transcriptomic analysis and in vivo bioluminescence imaging. PLoS One 7:e31808
doi: 10.1371/journal.pone.0031808
Chibber S, Farhan M, Hassan I, Naseem I (2011) White light-mediated Cu (II)-5FU interaction augments the chemotherapeutic potential of 5-FU: an in vitro study. Tumour Biol 32:881–892
doi: 10.1007/s13277-011-0189-y
David T, Peter HC, Gregory T, Catherine B, Saurabh S (2011) In vivo effects of immunomodulators in a murine model of fluorouracil-induced mucositis. Curr. Therapeutic Res 72:262–272
doi: 10.1016/j.curtheres.2011.11.003
Elhelaly AE, AlBasher G, Alfarraj S, Almeer R, Bahbah EI, Fouda MMA, Bungău SG, Aleya L, Abdel-Daim MM (2019) Protective effects of hesperidin and diosmin against acrylamide-induced liver, kidney, and brain oxidative damage in rats. Environ Sci Pollut Res 26:35151–35162
doi: 10.1007/s11356-019-06660-3
El-Sayyad IH, Hassan A (2013) Effects of adriamycin, cisplatin, and 5-fluorouracil on the testes of albino rats. Br J Med Health Sci 1:45–62 49
Farombi EO, Abarikwu SO, Adedara IA, Oyeyemi MO (2007) Kolaviron and curcumin ameliorate di-n-Butylphthalate-induced testicular toxicity in rats. Basic Clin Pharmacol Toxicol 100:43–48
doi: 10.1111/j.1742-7843.2007.00005.x
Gelen V, Şengül E (2018) Hematoprotective effect of naringin on 5-FU toxicity in rats. Chem Res J 3:127–130
Gelen V, Şengül E (2020) Antioxidant, antiinflammatory and antiapoptotic effects of naringin on cardiac damage induced by cisplatin. Indian J Tradit Knowl 19:459–465
Gelen V, Şengül E, Gedikli S, Atila G, Uslu H, Makav M (2017a) The protective effect of rutin and quercetin on 5-FU-induced hepatotoxicity in rats. Asian Pac J Trop Biomed 7:647–653
doi: 10.1016/j.apjtb.2017.06.013
Gelen V, Şengül E, Gedikli S, Gür C, Özkanlar S (2017b) Therapeutic effect of quercetin on renal function and tissue damage in the obesity induced rats. Biomed Pharmacother 89:524–528
doi: 10.1016/j.biopha.2017.02.057
Gelen V, Şengül E, Yıldırım S, Atila G (2018) The protective effects of naringin against 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats. Iran J Basic Med Sci 21:404–410
Gelen V, Gelen S.U, Celebi F, Cinar A, Yildirim S, Eser G (2019) The protective effect of Lactobacillus rhamnosus, Lactobacillus fermentum and Lactobacillus brevis against cisplatin-induced hepatic damage in rats. Fresenius Environ Bull 28:7583–7592.
Hussein M, Othman S (2011) Structure activity relationship of antioxidative property of hesperidin. International Journal of Pharmaceutical Research and Development 3:19–29
Inano H, Onoda M, Inafuku N, Kubota M, Kamada Y, Osawa T, Kobayashi H, Wakabayashi K (2000) Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats. Carcinogenesis 21:1835–1841
doi: 10.1093/carcin/21.10.1835
Ince S, Arslan Acaroz D, Neuwirth O, Demirel HH, Denk B, Kucukkurt I, Turkmen R (2014) Protective effect of polydatin, a natural precursor of resveratrol, against cisplatin induced toxicity in rats. Food Chem Toxicol 72:147–153
doi: 10.1016/j.fct.2014.07.022
Khan R, Sultana S (2011) Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats. Chem Biol Interact 192:193–200
doi: 10.1016/j.cbi.2011.03.009
Kinhult S, Albertsson M, Eskilsson J, Cwikiel M (2003) Effects of probucol on endothelial damage by 5-fluorouracil. Acta Oncol 42:304–308
doi: 10.1080/02841860310004409
Klinkhammer BM, Djudjaj S, Kunter U, Palsson R, Edvardsson VO, Wiech T, Thorsteinsdottir M, Hardarson S, Foresto-Neto O, Mulay SR, Moeller MJ, Jahnen-Dechent W, Floege J, Anders HJ, Boor P (2020) Cellular and molecular mechanisms of kidney injury in 2,8-dihydroxyadenine nephropathy. J Am Soc Nephrol 31:799–816
doi: 10.1681/ASN.2019080827
Lamberti M, Porto S, Marra M, Zappavigna S, Grimaldi A, Feola D, Pesce D, Naviglio S, Spina A, Sannolo N, Caraglia M (2012) 5-Fluorouracil induces apoptosis in rat cardiocytes through intracellular oxidative stress. J Exp Clin Cancer Res 19:31–60
Lawrence RA, Burk RF (1976) Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 71:952–958
doi: 10.1016/0006-291X(76)90747-6
Mercantepe F, Mercantepe T, Topcu A, Yılmaz A, Tumkaya L (2018) Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury. Naunyn Schmiedeberg's Arch Pharmacol 391:915–931
doi: 10.1007/s00210-018-1514-4
Middleton E Jr, Kandaswami C, Theoharides TC (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52:673–751
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ti A, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I (2010) 5-FU metabolism in cancer and orally-administrable 5-FU drugs. Cancers 2:1717–1730
doi: 10.3390/cancers2031717
Nada O (2010) A review of propolis antitumour action in vivo and in vitro. J. Api Product ApMed Sci 2:1–20
Naidu MU, Ramana GV, Rani PU, Mohan IK, Suman A, Pb R (2004) Chemotherapy-induced and/or radiation therapy-induced oral mucositis complicating the treatment of cancer. Neoplasia 6:423–431
doi: 10.1593/neo.04169
Nora E, Ali (2012) Protective effect of captopril against 5-fluorouracil-induced hepato and nephrotoxicity in male albino rats. J Am Sci:8
Placer ZA, Cushmanni LL, Johnson BC (1966) Estimation of products of lipid peroxidation (as malondialdehyde) in biochemical systems. Anal Biochem 16:359–364
doi: 10.1016/0003-2697(66)90167-9
Ramadori G, Cameron S (2010) Effects of systemic chemotherapy on the liver. Ann Hepatol 9:133–143.
Rashid S, Ali N, Nafees S, Ahmad S. Tanveer Arjumand W, Hasan S, Kazim Sultana S (2012) Alleviation of doxorubicin induced nephrotoxicity and hepatotoxicity by chrysin in Wistar rats. Toxicol Mech Methods 23:337–345.
Rashid S, Ali N, Nafees S, Ahmad S, Tanveer Hasan S, Kazim Sultana S (2013) Abrogation of 5-flourouracil induced renal toxicity by bee propolis via targeting oxidative stress and inflammation in Wistar rats. J Pharm Res 7:189–194
Sakat MS, Kilic K, Akdemir FNE, Yildirim S, Eser G, Kiziltunc A (2019) The effectiveness of eugenol against cisplatin-induced ototoxicity. Braz J Otorhinolaryngoly 85:766–773
doi: 10.1016/j.bjorl.2018.07.007
Sedlak J, Lindsay RH (1968) Estimation of total protein bound and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem 25:192–205
doi: 10.1016/0003-2697(68)90092-4
Selvaraj P, Pugalendi KV (2012) Efficacy of hesperidin on plasma, heart and liver tissue lipids in rats subjected to isoproterenol-induced cardiotoxicity. Exp Toxicol Pathol 64:449–452
doi: 10.1016/j.etp.2010.10.012
Şengül E, Gelen V, Gedikli S, Özkanlar S, Gür C, Çelebi F, Çınar A (2017) The protective effect of quercetin on cyclophosphamide-induced lung toxicity in rats. Biomed Pharmacother 92:303–307
doi: 10.1016/j.biopha.2017.05.047
Sengul E, Gelen SU, Yıldırım S, Çelebi F, Çınar A (2019) Probiotic bacteria attenuates cisplatin-induced nephrotoxicity through modulation of oxidative stress, inflammation and apoptosis in rats. Asian Pac J Trop Biomed 9:116
doi: 10.4103/2221-1691.254605
Sengul E, Gelen V, Gedikli S (2021a) Cardioprotectıve activities of quercetin and rutin in Sprague-Dawley rats treated wıth 5-fluorouracil. J Anim Plant Sci 31:423–443
Sengul E, Gelen V, Yildirim S, Tekin S, Dag Y (2021b) The effects of selenium in acrylamide-induced nephrotoxicity in rats: roles of oxidative stress, inflammation, apoptosis, and DNA damage. Biol Trace Elem Res 199:173–184
doi: 10.1007/s12011-020-02111-0
Stepniak J, Karbownik-Lewinska M (2016) 17 β-estradiol prevents experimentally-induced oxidative damage to membrane lipids and nuclear DNA in porcine ovary. Syst Biol Reprod Med 62:17–21
doi: 10.3109/19396368.2015.1101510
Suarez J, Herrera MD, Marhuenda E (1998) In vitro scavenger and antioxidant properties of hesperidin and neohesperidin dihydrochalcone. Phytomedicine 5:469–473
doi: 10.1016/S0944-7113(98)80044-5
Sun Y, Larry WO, Ying L (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34:497–500
doi: 10.1093/clinchem/34.3.497
Surh YJ, Chun KS, Cha HH (2001) Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: downregulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 1:243–268
doi: 10.1016/S0027-5107(01)00183-X
Thant AA, Wu Y, Lee J, Mishra DK, Garcia H, Koeffler HP, Vadgama JV (2008) Role of caspases in 5-FU and selenium-induced growth inhibition of colorectalcancer cells. Anticancer Res 28:3579–3592
Wang X, Morris ME (2007) Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2. Drug Metab Dispos 35:268–274
doi: 10.1124/dmd.106.011684
Yildirim S, Ozkan C, Huyut Z, Çınar A (2019) Detection of Se, vit. E, vit. A, MDA, 8-OHdG, and CoQ10 levels and histopathological changes in heart tissue in sheep with white muscle disease. Biol Trace Elem Res 188:419–423
doi: 10.1007/s12011-018-1434-7