Antibody Glycoengineering and Homogeneous Antibody-Drug Conjugate Preparation.
antibodies
conjugation
drug delivery
glycoprotein
glycosylation
Journal
Chemical record (New York, N.Y.)
ISSN: 1528-0691
Titre abrégé: Chem Rec
Pays: United States
ID NLM: 101085550
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
revised:
09
04
2021
received:
24
02
2021
accepted:
12
04
2021
pubmed:
23
4
2021
medline:
30
11
2021
entrez:
22
4
2021
Statut:
ppublish
Résumé
Antibody-drug conjugates (ADCs) are a class of biopharmaceuticals in which cytotoxic agents are conjugated to monoclonal antibodies (mAbs), allowing targeted drug delivery. Present heterogeneous ADCs (conjugated in random variable positions) suffered from issues of stability, reproducibility, efficacy, etc. Recent advances have led to the development of homogeneous ADC preparations by site-specific conjugation, allowing the control of the drug-to-antibody ratio. These approaches have increased the therapeutic window, efficacy, and batch-to-batch consistency of the ADC preparations. Antibodies carry a pair of heterogeneous N-glycans in the Fc regions, which are critical for antibody function. Drug conjugation through glycoengineering has been achieved with different approaches, including the use of endo-β-N-acetylglucosaminidase (ENGases) and monosaccharyl transferase mutants. In this article, we summarize different glycoengineering approaches for antibody-drug conjugation, and discuss their advantages for the development of next-generation homogeneous ADCs.
Identifiants
pubmed: 33886147
doi: 10.1002/tcr.202100054
doi:
Substances chimiques
Antibodies, Monoclonal
0
Immunoconjugates
0
Polysaccharides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3005-3014Subventions
Organisme : Grant-in-Aid for Scientific Research
ID : 19H03357
Organisme : Japan Society for the Promotion of Science
Organisme : Engineering Network Project
Informations de copyright
© 2021 The Chemical Society of Japan & Wiley-VCH GmbH.
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