Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity.
ABO Blood-Group System
/ genetics
Blood Grouping and Crossmatching
COVID-19
/ genetics
Chromosomes, Human, Pair 3
Databases, Genetic
Disease Susceptibility
Female
Galactosyltransferases
/ genetics
Genetic Predisposition to Disease
Genome-Wide Association Study
Hospitalization
Humans
Male
Middle Aged
Patient Acuity
Racial Groups
Risk Factors
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
01
10
2020
accepted:
22
03
2021
pubmed:
24
4
2021
medline:
22
6
2021
entrez:
23
4
2021
Statut:
ppublish
Résumé
COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal in others. Based on a study of 1,051,032 23andMe research participants, we report genetic and nongenetic associations with testing positive for SARS-CoV-2, respiratory symptoms and hospitalization. Using trans-ancestry genome-wide association studies, we identified a strong association between blood type and COVID-19 diagnosis, as well as a gene-rich locus on chromosome 3p21.31 that is more strongly associated with outcome severity. Hospitalization risk factors include advancing age, male sex, obesity, lower socioeconomic status, non-European ancestry and preexisting cardiometabolic conditions. While non-European ancestry was a significant risk factor for hospitalization after adjusting for sociodemographics and preexisting health conditions, we did not find evidence that these two primary genetic associations explain risk differences between populations for severe COVID-19 outcomes.
Identifiants
pubmed: 33888907
doi: 10.1038/s41588-021-00854-7
pii: 10.1038/s41588-021-00854-7
doi:
Substances chimiques
ABO Blood-Group System
0
ABO protein, human
EC 2.4.1.-
Galactosyltransferases
EC 2.4.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
801-808Investigateurs
Adrian Chubb
(A)
Alison Fitch
(A)
Alison Kung
(A)
Amanda Altman
(A)
Andy Kill
(A)
Jason Tan
(J)
Jeff Pollard
(J)
Jey McCreight
(J)
Jess Bielenberg
(J)
John Matthews
(J)
Johnny Lee
(J)
Lindsey Tran
(L)
Michelle Agee
(M)
Monica Royce
(M)
Nate Tang
(N)
Pooja Gandhi
(P)
Raffaello d'Amore
(R)
Ruth Tennen
(R)
Scott Dvorak
(S)
Scott Hadly
(S)
Sungmin Park
(S)
Taylor Morrow
(T)
Trung Le
(T)
Yiwen Zheng
(Y)
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