Amygdala physiology in pain.
Amygdala
chronic pain
emotions
neuroplasticity
pain modulation
synaptic plasticity
Journal
Handbook of behavioral neuroscience
ISSN: 1569-7339
Titre abrégé: Handb Behav Neurosci
Pays: Netherlands
ID NLM: 101472351
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
23
4
2021
pubmed:
1
1
2020
medline:
1
1
2020
Statut:
ppublish
Résumé
The amygdala has emerged as an important brain area for the emotional-affective dimension of pain and pain modulation. The amygdala receives nociceptive information through direct and indirect routes. These excitatory inputs converge on the amygdala output region (central nucleus) and can be modulated by inhibitory elements that are the target of (prefrontal) cortical modulation. For example, inhibitory neurons in the intercalated cell mass in the amygdala project to the central nucleus to serve gating functions, and so do inhibitory (PKCdelta) interneurons within the central nucleus. In pain conditions, synaptic plasticity develops in output neurons because of an excitation-inhibition imbalance and drives pain-like behaviors and pain persistence. Mechanisms of pain related neuroplasticity in the amygdala include classical transmitters, neuropeptides, biogenic amines, and various signaling pathways. An emerging concept is that differences in amygdala activity are associated with phenotypic differences in pain vulnerability and resilience and may be predetermining factors of the complexity and persistence of pain.
Identifiants
pubmed: 33889063
doi: 10.1016/b978-0-12-815134-1.00004-0
pmc: PMC8059430
mid: NIHMS1692413
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101-113Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA027096
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS118731
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS081121
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS038261
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106902
Pays : United States
Références
J Neurosci. 2011 Feb 9;31(6):2258-70
pubmed: 21307262
J Neurosci. 2016 Jan 20;36(3):837-50
pubmed: 26791214
J Neurophysiol. 2009 Oct;102(4):2253-64
pubmed: 19625541
Mol Pain. 2015 Aug 28;11:51
pubmed: 26311432
Am J Physiol Regul Integr Comp Physiol. 2006 Aug;291(2):R268-76
pubmed: 16614061
Mol Pain. 2010 Feb 08;6:10
pubmed: 20144185
Mol Pain. 2012 Jul 09;8:51
pubmed: 22776418
Nature. 2008 Jul 31;454(7204):642-5
pubmed: 18615014
Exp Neurol. 2008 Sep;213(1):48-56
pubmed: 18599044
J Pain. 2014 Feb;15(2):197-203
pubmed: 24212070
Mol Pain. 2013 Aug 12;9:41
pubmed: 23937887
J Neurosci. 2012 Oct 10;32(41):14217-26
pubmed: 23055491
Neuroscience. 2006;139(3):1039-48
pubmed: 16527423
Physiol Behav. 2006 Jun 15;88(1-2):67-76
pubmed: 16647726
J Neurosci. 2013 Sep 11;33(37):14729-37
pubmed: 24027273
Neuron. 2008 Nov 26;60(4):570-81
pubmed: 19038215
Pain. 2007 Jan;127(1-2):161-72
pubmed: 17055162
Neuroimage Clin. 2017 Jun 02;15:449-457
pubmed: 28649489
J Neurosci. 2008 Apr 9;28(15):3861-76
pubmed: 18400885
J Comp Neurol. 2005 Aug 15;489(1):92-119
pubmed: 15977170
J Neurophysiol. 2013 Oct;110(8):1765-81
pubmed: 23883857
J Physiol. 2005 May 1;564(Pt 3):907-21
pubmed: 15760935
Brain Res Rev. 2009 Apr;60(1):214-25
pubmed: 19146877
Eur J Pain. 2012 Jan;16(1):61-71
pubmed: 21684787
Brain. 2016 Jul;139(Pt 7):1958-70
pubmed: 27190016
Brain Res Bull. 1994;33(5):529-34
pubmed: 8186998
J Neurosci. 2005 Nov 16;25(46):10717-28
pubmed: 16291945
Gastroenterology. 2003 Jun;124(7):1738-47
pubmed: 12806606
Behav Neurosci. 2010 Jun;124(3):391-7
pubmed: 20528083
Pain. 2005 Jun;115(3):398-409
pubmed: 15911167
Nature. 2017 Feb 2;542(7639):96-100
pubmed: 28117439
J Neurophysiol. 2004 Jan;91(1):13-24
pubmed: 13679408
J Pain. 2012 Apr;13(4):328-37
pubmed: 22424916
J Neurosci. 2017 Mar 1;37(9):2292-2304
pubmed: 28137966
Neurosci Lett. 2008 Oct 10;443(3):184-7
pubmed: 18687383
Physiol Rev. 2010 Apr;90(2):419-63
pubmed: 20393190
Anat Rec (Hoboken). 2017 Aug;300(8):1481-1501
pubmed: 28263454
Neuroscience. 2002;112(3):605-17
pubmed: 12074902
Eur J Pharmacol. 2015 Feb 15;749:151-60
pubmed: 25576174
Front Cell Neurosci. 2016 May 24;10:133
pubmed: 27252623
J Neurosci. 2018 May 16;38(20):4829-4839
pubmed: 29695413
Neuropsychopharmacology. 2011 Jan;36(2):529-38
pubmed: 20962768
Neuroscience. 2010 Feb 17;165(4):1402-11
pubmed: 19925853
Pain. 2014 Sep;155(9):1727-1742
pubmed: 24861582
J Neurophysiol. 2011 Aug;106(2):960-73
pubmed: 21613584
J Comp Neurol. 1993 Mar 8;329(2):201-29
pubmed: 8454730
Nat Rev Neurosci. 2013 Jul;14(7):502-11
pubmed: 23719569
Neurosci Lett. 1996 Sep 13;215(3):165-8
pubmed: 8899739
Nat Neurosci. 2010 Apr;13(4):489-94
pubmed: 20208529
Front Hum Neurosci. 2016 Jul 26;10:366
pubmed: 27507939
Neuron. 2017 Jan 4;93(1):164-178
pubmed: 28017470
Mol Pain. 2007 Jun 05;3:13
pubmed: 17550594
Neuroscience. 2011 Mar 31;178:208-17
pubmed: 21256929
Cell Rep. 2018 May 1;23(5):1301-1313
pubmed: 29719246
Neuropharmacology. 2011 Dec;61(8):1334-44
pubmed: 21854791
J Neurosci. 2010 Apr 14;30(15):5451-64
pubmed: 20392966
Eur J Neurosci. 2017 Sep;46(6):2149-2160
pubmed: 28833700
J Physiol. 2018 Dec;596(24):6289-6305
pubmed: 30281797
J Neurosci. 2004 Nov 17;24(46):10410-5
pubmed: 15548656
eNeuro. 2017 Mar 24;4(1):
pubmed: 28374004
Brain Struct Funct. 2018 Jul;223(6):2627-2639
pubmed: 29550939
J Neurosci. 2011 Jan 19;31(3):1114-27
pubmed: 21248136
J Neurosci. 2005 Aug 24;25(34):7754-62
pubmed: 16120776
J Neurosci. 2007 Feb 14;27(7):1543-51
pubmed: 17301163
Mol Pain. 2014 May 29;10:32
pubmed: 24884567
Eur J Neurosci. 2014 Feb;39(3):455-66
pubmed: 24494685
J Neurosci. 2017 Feb 8;37(6):1378-1393
pubmed: 28011743
J Physiol. 2007 Jun 15;581(Pt 3):961-70
pubmed: 17379642
Pain. 2005 Jan;113(1-2):211-22
pubmed: 15621382
Neuroscientist. 2004 Jun;10(3):221-34
pubmed: 15155061
Am J Med. 2003 Aug 18;115 Suppl 3A:31S-38S
pubmed: 12928072
Mol Pain. 2010 Sep 22;6:60
pubmed: 20860833
Neurosci Lett. 2004 May 6;361(1-3):254-7
pubmed: 15135941
ACS Chem Neurosci. 2018 Sep 19;9(9):2252-2261
pubmed: 29630339
J Mol Psychiatry. 2013 Jun 05;1(1):9
pubmed: 25408902
Pain. 1979 Jun;6(3):249
pubmed: 460932
Neuropharmacology. 2018 Aug;138:219-231
pubmed: 29908238
Mol Pain. 2008 Jul 16;4:26
pubmed: 18631385
Regul Pept. 2007 Jun 7;141(1-3):105-12
pubmed: 17335920
J Neurophysiol. 2007 Jun;97(6):3893-904
pubmed: 17392412
Eur J Neurosci. 2012 Nov;36(9):3204-13
pubmed: 22861166
Eur J Pain. 2005 Aug;9(4):463-84
pubmed: 15979027
J Comp Neurol. 2004 Jan 1;468(1):24-56
pubmed: 14648689
J Neurosci. 2016 Sep 7;36(36):9391-406
pubmed: 27605614
Curr Opin Neurobiol. 2010 Apr;20(2):231-5
pubmed: 20303254
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2423-8
pubmed: 19171885
Exp Brain Res. 1998 Sep;122(2):165-74
pubmed: 9776515
Front Neurosci. 2015 Dec 24;9:487
pubmed: 26733798
Nat Commun. 2015 Jul 16;6:7660
pubmed: 26179626
eNeuro. 2018 Feb 6;5(1):
pubmed: 29445764
J Neurophysiol. 2006 Oct;96(4):1803-15
pubmed: 16760343
Brain. 2002 Jun;125(Pt 6):1326-36
pubmed: 12023321
Neurosci Lett. 1989 May 22;100(1-3):83-8
pubmed: 2474780
J Neurosci Res. 1999 Dec 1;58(5):663-73
pubmed: 10561694
Behav Brain Res. 2010 May 1;209(1):174-8
pubmed: 20097232
Prog Neurobiol. 2011 Mar;93(3):385-404
pubmed: 21216272
Pain. 2004 Mar;108(1-2):129-36
pubmed: 15109516
Hum Brain Mapp. 2014 Feb;35(2):527-38
pubmed: 23097300
J Neurophysiol. 2003 Feb;89(2):716-27
pubmed: 12574449
J Neurosci. 2010 Jan 20;30(3):832-7
pubmed: 20089891
Nature. 2015 Jan 15;517(7534):284-92
pubmed: 25592533
Mol Pain. 2008 Oct 25;4:47
pubmed: 18950528
Pain. 2017 Apr;158(4):747-759
pubmed: 28225716
J Neurophysiol. 2008 Mar;99(3):1201-12
pubmed: 18171711
J Neurosci. 2011 Mar 23;31(12):4687-97
pubmed: 21430167
Mol Pain. 2010 Dec 16;6:93
pubmed: 21162731
Mol Pain. 2013 Feb 15;9:2
pubmed: 23410057
J Neurophysiol. 2011 Jun;105(6):3054-66
pubmed: 21471396
J Neurosci. 2008 Aug 6;28(32):8074-85
pubmed: 18685032
J Neurosci. 2003 Jan 1;23(1):52-63
pubmed: 12514201
Neuroscience. 2008 Aug 26;155(3):959-68
pubmed: 18620025
AJNR Am J Neuroradiol. 2016 Jun;37(6):1139-45
pubmed: 26767708
Pain. 2017 Dec;158(12):2376-2385
pubmed: 28832396
Gastroenterology. 2011 Jan;140(1):91-100
pubmed: 20696168
Handb Exp Pharmacol. 2015;227:261-84
pubmed: 25846623
Physiology (Bethesda). 2008 Dec;23:371-80
pubmed: 19074744
Mol Brain. 2014 Oct 04;7:72
pubmed: 25277376
Neuron. 2014 Jun 4;82(5):966-80
pubmed: 24908482
J Dent Res. 2016 Jun;95(6):605-12
pubmed: 26965423
J Neurophysiol. 2016 Jun 1;115(6):2721-39
pubmed: 26888105
eNeuro. 2016 Mar 21;3(2):
pubmed: 27022632
Pain Res Manag. 2017;2017:8296501
pubmed: 29302197
Cell Rep. 2015 Aug 4;12(5):752-9
pubmed: 26212331
J Neurosci. 2008 Feb 6;28(6):1398-403
pubmed: 18256259
Neuropharmacology. 2008 Sep;55(4):537-45
pubmed: 18533199
J Pain. 2010 Dec;11(12):1461-71
pubmed: 20624690
J Neurosci. 2010 Jun 16;30(24):8203-13
pubmed: 20554871
Curr Opin Neurobiol. 2012 Aug;22(4):717-23
pubmed: 22424846
J Neurophysiol. 2002 Jan;87(1):103-12
pubmed: 11784733
Mol Pain. 2008 Jun 23;4:24
pubmed: 18573207
Pain. 2007 Jan;127(1-2):17-26
pubmed: 16965855
Nature. 2010 Nov 11;468(7321):270-6
pubmed: 21068836
Sci Rep. 2018 Sep 11;8(1):13608
pubmed: 30206257
J Neurophysiol. 2011 Nov;106(5):2642-52
pubmed: 21880942
J Neurosci. 2014 Feb 12;34(7):2432-7
pubmed: 24523533
Mol Pain. 2018 Jan-Dec;14:1744806918807102
pubmed: 30270724
Pain. 2002 Sep;99(1-2):313-21
pubmed: 12237210
Pain. 2004 Jul;110(1-2):112-22
pubmed: 15275758
Mol Pain. 2018 Jan-Dec;14:1744806918804441
pubmed: 30209982
Cephalalgia. 2013 Nov;33(15):1264-8
pubmed: 23720503
J Neurophysiol. 1992 Aug;68(2):551-69
pubmed: 1527575
Brain Res. 2006 Feb 3;1071(1):91-6
pubmed: 16423333