A mechanical model of early somite segmentation.
Developmental Biology
Mechanical Modeling
Poultry Embryology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
23 Apr 2021
23 Apr 2021
Historique:
received:
23
09
2020
revised:
15
01
2021
accepted:
12
03
2021
entrez:
23
4
2021
pubmed:
24
4
2021
medline:
24
4
2021
Statut:
epublish
Résumé
Somitogenesis is often described using the clock-and-wavefront (CW) model, which does not explain how molecular signaling rearranges the pre-somitic mesoderm (PSM) cells into somites. Our scanning electron microscopy analysis of chicken embryos reveals a caudally-progressing epithelialization front in the dorsal PSM that precedes somite formation. Signs of apical constriction and tissue segmentation appear in this layer 3-4 somite lengths caudal to the last-formed somite. We propose a mechanical instability model in which a steady increase of apical contractility leads to periodic failure of adhesion junctions within the dorsal PSM and positions the future inter-somite boundaries. This model produces spatially periodic segments whose size depends on the speed of the activation front of contraction (
Identifiants
pubmed: 33889816
doi: 10.1016/j.isci.2021.102317
pii: S2589-0042(21)00285-6
pmc: PMC8050378
doi:
Types de publication
Journal Article
Langues
eng
Pagination
102317Informations de copyright
© 2021.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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