RNA sequencing and proteomic profiling reveal different alterations by dietary methylmercury in the hippocampal transcriptome and proteome in BALB/c mice.
RNA sequencing
hippocampus
methylmercury
mice
proteomic
Journal
Metallomics : integrated biometal science
ISSN: 1756-591X
Titre abrégé: Metallomics
Pays: England
ID NLM: 101478346
Informations de publication
Date de publication:
24 05 2021
24 05 2021
Historique:
received:
04
12
2020
revised:
12
04
2021
accepted:
13
04
2021
pubmed:
24
4
2021
medline:
28
12
2021
entrez:
23
4
2021
Statut:
ppublish
Résumé
Methylmercury (MeHg) is a highly neurotoxic form of mercury (Hg) present in seafood. Here, we recorded and compared proteomic and transcriptomic changes in hippocampus of male BALB/c mice exposed to two doses of MeHg. Mice were fed diets spiked with 0.28 mg MeHg kg-1, 5 mg MeHg kg-1, or an unspiked control diet for 77 days. Total mercury content was significantly (P < 0.05) increased in brain tissue of both MeHg-exposed groups (18 ± 2 mg Hg kg-1 and 0.56 ± 0.06 mg Hg kg-1). Hippocampal protein and ribonucleic acid (RNA) expression levels were significantly altered both in tissues from mice receiving a low dose MeHg (20 proteins/294 RNA transcripts) and a high dose MeHg (61 proteins/876 RNA transcripts). The majority but not all the differentially expressed features in hippocampus were dose dependent. The combined use of transcriptomic and proteomic profiling data provided insight on the influence of MeHg on neurotoxicity, energy metabolism, and oxidative stress through several regulated features and pathways, including RXR function and superoxide radical degradation.
Identifiants
pubmed: 33890672
pii: 6247627
doi: 10.1093/mtomcs/mfab022
pmc: PMC8716076
pii:
doi:
Substances chimiques
Methylmercury Compounds
0
Proteome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press.
Références
Genome Biol. 2014;15(12):550
pubmed: 25516281
BMC Genomics. 2016 Aug 05;17:554
pubmed: 27496535
Nat Protoc. 2016 Dec;11(12):2301-2319
pubmed: 27809316
J Trace Elem Med Biol. 2016 Dec;38:99-107
pubmed: 26987277
Environ Res. 1998 May;77(2):73-8
pubmed: 9600798
J Expo Sci Environ Epidemiol. 2020 May;30(3):504-514
pubmed: 32015433
Proteomics. 2015 Mar;15(5-6):1051-74
pubmed: 25164579
Nat Commun. 2020 Feb 5;11(1):735
pubmed: 32024846
Crit Rev Toxicol. 1995;25(1):1-24
pubmed: 7734058
Food Chem Toxicol. 2018 Aug;118:608-625
pubmed: 29883783
Toxicol Res (Camb). 2012 Jul 1;1(1):32-38
pubmed: 27795823
Environ Sci Technol. 2010 Jan 1;44(1):469-75
pubmed: 20039754
Am J Dis Child. 1976 Oct;130(10):1070-6
pubmed: 973609
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Environ Pollut. 2018 Jul;238:213-221
pubmed: 29554569
Autoimmun Rev. 2017 Jan;16(1):72-80
pubmed: 27666813
Neurosci Biobehav Rev. 2000 Jun;24(4):417-63
pubmed: 10817843
J Proteome Res. 2009 Nov;8(11):4966-82
pubmed: 19737024
Antioxid Redox Signal. 2011 Sep 15;15(6):1583-606
pubmed: 21473702
Environ Health Perspect. 2012 Jun;120(6):799-806
pubmed: 22275730
Environ Res. 2015 Nov;143(Pt A):55-61
pubmed: 26436307
Environ Sci Technol. 2005 Aug 1;39(15):5703-8
pubmed: 16124305
Environ Res. 1998 May;77(2):165-72
pubmed: 9600810
J Neural Transm (Vienna). 2018 Jun;125(6):913-923
pubmed: 29488099
Sci Total Environ. 2020 Apr 1;711:135117
pubmed: 31831233
J AOAC Int. 2007 May-Jun;90(3):844-56
pubmed: 17580639
Toxicol Lett. 2013 Oct 24;222(2):189-96
pubmed: 23872261
Toxicol Appl Pharmacol. 2011 Nov 1;256(3):405-17
pubmed: 21601588
Biochem Soc Trans. 2017 Apr 15;45(2):465-475
pubmed: 28408487
Chemosphere. 2020 Apr;245:125586
pubmed: 31881386
J Atten Disord. 2021 Feb;25(4):572-583
pubmed: 30623719
Toxicology. 2016 Mar 10;347-349:29-39
pubmed: 27012723
Int J Environ Res Public Health. 2015 Jul 31;12(8):9054-67
pubmed: 26264017
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
Sci Total Environ. 2012 Nov 15;439:220-9
pubmed: 23069934
Nihon Eiseigaku Zasshi. 2017;72(3):140-148
pubmed: 28931792
Environ Pollut. 2008 Nov;156(2):359-66
pubmed: 18367299
Life Sci. 2011 Oct 10;89(15-16):555-63
pubmed: 21683713
J Proteome Res. 2011 Apr 1;10(4):1794-805
pubmed: 21254760
Adv Neurobiol. 2017;18:267-286
pubmed: 28889272
Sci Total Environ. 1987 Sep;65:53-62
pubmed: 3685941
Environ Sci Pollut Res Int. 2014 Jun;21(12):7466-79
pubmed: 24590602
Arch Toxicol. 2017 Jan;91(1):63-81
pubmed: 27422290
Toxicol Sci. 2009 Aug;110(2):389-400
pubmed: 19465457
J Appl Toxicol. 1985 Jun;5(3):148-59
pubmed: 4008862
J Biomed Biotechnol. 2012;2012:681016
pubmed: 22899888
Environ Pollut. 2002;116(2):265-71
pubmed: 11806454
Sci Total Environ. 2010 Jan 1;408(3):537-42
pubmed: 19880158
Nat Rev Genet. 2012 Mar 13;13(4):227-32
pubmed: 22411467
Sci Total Environ. 2010 Sep 15;408(20):4841-7
pubmed: 20619878
Nat Rev Genet. 2015 Feb;16(2):85-97
pubmed: 25582081
Proc Natl Acad Sci U S A. 1988 Jun;85(12):4538-42
pubmed: 3380805
Toxicol In Vitro. 2019 Jun;57:96-104
pubmed: 30776503
Sci Total Environ. 1996 Jul 16;186(1-2):95-104
pubmed: 8685711
Environ Toxicol Pharmacol. 2016 Dec;48:203-213
pubmed: 27816841
J Toxicol Environ Health A. 2016;79(12):502-12
pubmed: 27294299
J Trace Elem Med Biol. 2018 Jul;48:196-201
pubmed: 29773181
Aquat Toxicol. 2010 Oct 1;100(1):51-65
pubmed: 20701987
J Neurol Sci. 2007 Nov 15;262(1-2):131-44
pubmed: 17681548
J Neurophysiol. 2014 Sep 15;112(6):1559-65
pubmed: 24944211
Science. 1973 Jul 20;181(4096):230-41
pubmed: 4719063
J Proteome Res. 2013 Nov 1;12(11):5233-45
pubmed: 23984759
Environ Sci Pollut Res Int. 2018 Aug;25(22):21937-21948
pubmed: 29797195
Ecotoxicol Environ Saf. 2018 Jan;147:299-305
pubmed: 28858702
Neurotoxicology. 2016 Dec;57:136-144
pubmed: 27677934
Toxicology. 2016 Mar 10;347-349:1-5
pubmed: 26945727
Lancet. 1958 Sep 20;2(7047):629-31
pubmed: 13588955
Nat Methods. 2009 May;6(5):359-62
pubmed: 19377485
Sci Total Environ. 2019 Feb 20;652:1482-1496
pubmed: 30586833
Toxicology. 2014 Jul 3;321:1-12
pubmed: 24680724
Metallomics. 2019 Feb 20;11(2):390-403
pubmed: 30525157
Int J Environ Res Public Health. 2018 Mar 12;15(3):
pubmed: 29534534
Int J Mol Sci. 2017 Mar 29;18(4):
pubmed: 28353644
Environ Health Perspect. 2000 Jun;108 Suppl 3:511-33
pubmed: 10852851
Toxicol Sci. 2015 Jul;146(1):43-51
pubmed: 25809596
J Trace Elem Med Biol. 2019 Jan;51:19-27
pubmed: 30466930
Environ Health. 2008 Oct 29;7:53
pubmed: 18959803
Int J Hyg Environ Health. 2018 May;221(4):697-703
pubmed: 29567374
Nat Methods. 2016 Sep;13(9):731-40
pubmed: 27348712
Sci Total Environ. 2018 Jun 1;626:668-677
pubmed: 29396333
Neurotoxicology. 2007 May;28(3):587-93
pubmed: 17267038
J Biol Regul Homeost Agents. 2003 Jan-Mar;17(1):29-45
pubmed: 12757020
Environ Health Perspect. 2002 Feb;110 Suppl 1:11-23
pubmed: 11834460
Expert Rev Proteomics. 2005 Oct;2(5):767-80
pubmed: 16209655