APOE4 genotype exacerbates the impact of menopause on cognition and synaptic plasticity in APOE-TR mice.
Animals
Apolipoprotein E3
/ physiology
Apolipoprotein E4
/ physiology
Behavior, Animal
Carcinogens
/ toxicity
Cognition Disorders
/ etiology
Cyclohexenes
/ toxicity
Female
Memory Disorders
/ etiology
Menopause
Mice
Mice, Inbred C57BL
Mice, Knockout
Neuronal Plasticity
Ovarian Diseases
/ chemically induced
Vinyl Compounds
/ toxicity
4-vinylcyclohexene diepoxide
Alzheimer’s disease
docosahexaenoic acid
recognition memory
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
19
03
2021
received:
01
12
2020
accepted:
25
03
2021
entrez:
23
4
2021
pubmed:
24
4
2021
medline:
20
7
2021
Statut:
ppublish
Résumé
The impact of sex and menopausal status in Alzheimer's disease remains understudied despite increasing evidence of greater female risk, particularly in APOE4 carriers. Utilizing female APOE-TR mice maintained on a high-fat diet background we induced ovarian failure through repeated VCD injections, to mimic human menopause. At 12 months of age, recognition memory and spatial memory were assessed using object recognition, Y-maze spontaneous alternation, and Barnes maze. A VCD*genotype interaction reduced the recognition memory (P < .05), with APOE4 VCD-treated animals unable to distinguish between novel and familiar objects. APOE4 mice displayed an additional 37% and 12% reduction in Barnes (P < .01) and Y-maze (P < .01) performance, indicative of genotype-specific spatial memory impairment. Molecular analysis indicated both VCD and genotype-related deficits in synaptic plasticity with BDNF, Akt, mTOR, and ERK signaling compromised. Subsequent reductions in the transcription factors Creb1 and Atf4 were also evident. Furthermore, the VCD*genotype interaction specifically diminished Ephb2 expression, while Fos, and Cnr1 expression reduced as a consequence of APOE4 genotype. Brain DHA levels were 13% lower in VCD-treated animals independent of genotype. Consistent with this, we detected alterations in the expression of the DHA transporters Acsl6 and Fatp4. Our results indicate that the combination of ovarian failure and APOE4 leads to an exacerbation of cognitive and neurological deficits.
Identifiants
pubmed: 33891334
doi: 10.1096/fj.202002621RR
doi:
Substances chimiques
Apolipoprotein E3
0
Apolipoprotein E4
0
Carcinogens
0
Cyclohexenes
0
Vinyl Compounds
0
4-vinyl-1-cyclohexene dioxide
596C064IG4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e21583Subventions
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
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