Feasibility and safety of whole lung irradiation in the treatment of canine appendicular osteosarcoma.
bone tumour
clinical trial
lung radiation effects
pulmonary metastasis
radiation oncology
Journal
Veterinary and comparative oncology
ISSN: 1476-5829
Titre abrégé: Vet Comp Oncol
Pays: England
ID NLM: 101185242
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
19
04
2021
received:
21
01
2021
accepted:
20
04
2021
pubmed:
24
4
2021
medline:
1
4
2022
entrez:
23
4
2021
Statut:
ppublish
Résumé
Whole lung irradiation (WLI) has been used successfully in humans as an adjuvant treatment for osteosarcoma. The aim of this study is to describe the feasibility and safety of WLI in dogs with appendicular osteosarcoma. Twelve client-owned dogs with appendicular osteosarcoma that had successfully completed amputation and four doses of carboplatin without evidence of gross metastasis were enrolled in this prospective clinical trial. Ten once-daily fractions of 1.75 Gy were administered to the planning target volume encompassing the lungs. Overall, WLI was well tolerated in these patients. No dogs developed symptoms of pneumonitis or pulmonary fibrosis. Haematopoietic toxicity evaluated during radiation therapy was found to be mild. The median disease free interval for WLI treated dogs was not significantly different than the median DFI for a group of historic control dogs (376 days for WLI treated dogs versus 304.5 days for control dogs; p = 0.5461). Although no significant improvement in outcome was observed with this study, WLI appears to be safe in dogs and warrants further investigation to characterize the efficacy and toxicity.
Identifiants
pubmed: 33891368
doi: 10.1111/vco.12702
pmc: PMC9290556
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
20-28Subventions
Organisme : American College of Veterinary Internal Medicine
ID : 535767
Organisme : Katherine and Rebecca Rochelle Chair in Oncology
Organisme : Texas A&M GINN Grant
Informations de copyright
© 2021 The Authors. Veterinary and Comparative Oncology published by John Wiley & Sons Ltd.
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