Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors.
Animals
Antiviral Agents
/ chemical synthesis
COVID-19
/ metabolism
Chlorocebus aethiops
Coronavirus 3C Proteases
/ antagonists & inhibitors
Cysteine Proteinase Inhibitors
/ chemical synthesis
Dose-Response Relationship, Drug
Drug Design
Humans
Microbial Sensitivity Tests
Models, Molecular
Molecular Structure
Proline
/ analogs & derivatives
Pyrrolidines
/ chemical synthesis
SARS-CoV-2
/ drug effects
Sulfonic Acids
/ chemical synthesis
Vero Cells
COVID-19 Drug Treatment
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
24 02 2022
24 02 2022
Historique:
pubmed:
24
4
2021
medline:
3
3
2022
entrez:
23
4
2021
Statut:
ppublish
Résumé
The main protease (M
Identifiants
pubmed: 33891389
doi: 10.1021/acs.jmedchem.1c00509
pmc: PMC8536799
mid: NIHMS1713383
doi:
Substances chimiques
Antiviral Agents
0
Cysteine Proteinase Inhibitors
0
Pyrrolidines
0
Sulfonic Acids
0
N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide
89BT58KELH
Proline
9DLQ4CIU6V
3C-like proteinase, SARS-CoV-2
EC 3.4.22.-
Coronavirus 3C Proteases
EC 3.4.22.28
GC376
H1NMJ5XDG5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2848-2865Subventions
Organisme : NIAID NIH HHS
ID : R33 AI119187
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM128624
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI151638
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI157046
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008804
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI147325
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI158775
Pays : United States
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