Leptin Induces Epigenetic Regulation of Transient Receptor Potential Melastatin 7 in Rat Adrenal Pheochromocytoma Cells.
DNA methylation
LEPRb
TRPM7
histone modifications
leptin
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
pubmed:
24
4
2021
medline:
14
9
2021
entrez:
23
4
2021
Statut:
ppublish
Résumé
Obesity elevates the plasma level of leptin, which has been associated with hypertension. Our recent studies in mice demonstrated that leptin increases blood pressure by activating the carotid sinus nerve, which transmits the chemosensory input from carotid bodies (CBs) to the medullary centers, and that the effect of leptin is mediated via
Identifiants
pubmed: 33891828
doi: 10.1165/rcmb.2020-0374OC
pmc: PMC8399575
doi:
Substances chimiques
Leptin
0
Neoplasm Proteins
0
TRPM Cation Channels
0
Trpm7 protein, rat
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
214-221Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK089503
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128970
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133100
Pays : United States
Commentaires et corrections
Type : CommentIn
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