Targeting cell-cycle machinery in cancer.
Journal
Cancer cell
ISSN: 1878-3686
Titre abrégé: Cancer Cell
Pays: United States
ID NLM: 101130617
Informations de publication
Date de publication:
14 06 2021
14 06 2021
Historique:
received:
24
11
2020
revised:
09
02
2021
accepted:
26
03
2021
pubmed:
24
4
2021
medline:
18
12
2021
entrez:
23
4
2021
Statut:
ppublish
Résumé
Abnormal activity of the core cell-cycle machinery is seen in essentially all tumor types and represents a driving force of tumorigenesis. Recent studies revealed that cell-cycle proteins regulate a wide range of cellular functions, in addition to promoting cell division. With the clinical success of CDK4/6 inhibitors, it is becoming increasingly clear that targeting individual cell-cycle components may represent an effective anti-cancer strategy. Here, we discuss the potential of inhibiting different cell-cycle proteins for cancer therapy.
Identifiants
pubmed: 33891890
pii: S1535-6108(21)00168-9
doi: 10.1016/j.ccell.2021.03.010
pmc: PMC8206013
mid: NIHMS1695086
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Cyclin D
0
Cyclin E
0
CDK4 protein, human
EC 2.7.11.22
CDK6 protein, human
EC 2.7.11.22
Cyclin-Dependent Kinase 4
EC 2.7.11.22
Cyclin-Dependent Kinase 6
EC 2.7.11.22
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
759-778Subventions
Organisme : NCI NIH HHS
ID : P50 CA168504
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA202634
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA236226
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA247375
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests P.S. has been a consultant at Novartis, Genovis, Guidepoint, The Planning Shop, ORIC Pharmaceuticals, Cedilla Therapeutics, Syros Pharmaceuticals and Exo Therapeutics; his laboratory received research funding from Novartis.
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