Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor.
allosteric regulation
binding
electrostatics
isothermal titration calorimetry
linkage
major histocompatibility complex
natural killer cells
protein dynamics
thermodynamics
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
Historique:
received:
20
10
2020
revised:
14
04
2021
accepted:
19
04
2021
pubmed:
24
4
2021
medline:
21
8
2021
entrez:
23
4
2021
Statut:
ppublish
Résumé
Using a variety of activating and inhibitory receptors, natural killer (NK) cells protect against disease by eliminating cells that have downregulated class I major histocompatibility complex (MHC) proteins, such as in response to cell transformation or viral infection. The inhibitory murine NK receptor Ly49C specifically recognizes the class I MHC protein H-2K
Identifiants
pubmed: 33891944
pii: S0021-9258(21)00475-0
doi: 10.1016/j.jbc.2021.100686
pmc: PMC8138769
pii:
doi:
Substances chimiques
NK Cell Lectin-Like Receptor Subfamily A
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
100686Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM118166
Pays : United States
Organisme : NIH HHS
ID : S10 OD028553
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002529
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.
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