Doxycycline-doped membranes induced osteogenic gene expression on osteoblastic cells.

Cell Differentiation Doxycycline Gene Expression Osteoblasts Osteogenesis Silicon Dioxide
Doxycycline GBR Gene expression Membrane RT-qPCR

Journal

Journal of dentistry
ISSN: 1879-176X
Titre abrégé: J Dent
Pays: England
ID NLM: 0354422

Informations de publication

Date de publication:
06 2021
Historique:
received: 21 01 2021
revised: 18 03 2021
accepted: 15 04 2021
pubmed: 24 4 2021
medline: 30 6 2021
entrez: 23 4 2021
Statut: ppublish

Résumé

To analyze how novel developed silicon dioxide composite membranes, functionalized with zinc or doxycycline, can modulate the expression of genes related to the osteogenic functional capacity of osteoblastic cells. The composite nanofibers membranes were manufactured by using a novel polymeric blend and 20 nm silicon dioxide nanoparticles (SiO In general, the blending of SiO Zinc and doxycycline doped membranes are bioactive inducing overexpression of several osteogenic gene markers. Doxycycline doped membranes may be a potential candidate for use in GBR procedures in several challenging pathologies, including periodontal diseases.

Identifiants

DOI: 10.1016/j.jdent.2021.103676 PMID: 33891990
pubmed: 33891990
pii: S0300-5712(21)00097-X
doi: 10.1016/j.jdent.2021.103676
pii:
doi:

Substances chimiques

Silicon Dioxide 7631-86-9
Doxycycline N12000U13O

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103676

Informations de copyright

Copyright © 2021. Published by Elsevier Ltd.

Auteurs

Manuel Toledano-Osorio (M)

Biomaterials in Dentistry Research Group, Department of Stomatology, School of Dentistry, University of Granada, Spain; Medicina Clínica y Salud Pública PhD Programme, Spain.

Francisco Javier Manzano-Moreno (FJ)

Biomedical Group (BIO277), Department of Stomatology, School of Dentistry, University of Granada, Spain; Instituto Investigación Biosanitaria, ibs, Granada, Granada, Spain.

Manuel Toledano (M)

Biomaterials in Dentistry Research Group, Department of Stomatology, School of Dentistry, University of Granada, Spain. Electronic address: toledano@ugr.es.

Raquel Osorio (R)

Biomaterials in Dentistry Research Group, Department of Stomatology, School of Dentistry, University of Granada, Spain.

Antonio L Medina-Castillo (AL)

NanoMyP®, Nanomateriales y Polimeros S.L., Spin-Off company of the University of Granada, Edificio BIC-Granada. Av. Innovación 1. 18016 - Armilla, Granada, Spain.

Víctor J Costela-Ruiz (VJ)

Instituto Investigación Biosanitaria, ibs, Granada, Granada, Spain; Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Spain.

Concepción Ruiz (C)

Instituto Investigación Biosanitaria, ibs, Granada, Granada, Spain; Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Spain; Institute of Neuroscience, University of Granada, Centro de Investigación Biomédica (CIBM), Parque de Tecnológico de la Salud (PTS), Granada, Spain.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Doxycycline-doped membranes induced osteogenic...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtacènes › Tétracyclines › Doxycycline › Doxycycline-doped membranes induced osteogenic...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Doxycycline-doped membranes induced osteogenic...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Doxycycline-doped membranes induced osteogenic...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › Doxycycline-doped membranes induced osteogenic...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du silicium › Silice › Doxycycline-doped membranes induced osteogenic...