Rosette morphology in zona glomerulosa formation and function.
Adherent junction
Adrenal cortex
Aldosterone
Calcium signaling
Cyp11b2
Epithelial remodeling
FGFR2
GCaMP3
Morphogenesis
Optopatch
Rosette
Zona fasciculata
Zona glomerulosa
Zonal transdifferentiation
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
15 06 2021
15 06 2021
Historique:
received:
28
01
2021
revised:
29
03
2021
accepted:
13
04
2021
pubmed:
24
4
2021
medline:
15
12
2021
entrez:
23
4
2021
Statut:
ppublish
Résumé
How morphology informs function is a fundamental biological question. Here, we review the morphological features of the adrenal zona glomerulosa (zG), highlighting recent cellular and molecular discoveries that govern its formation. The zG consists of glomeruli enwrapped in a Laminin-β1-enriched basement membrane (BM). Within each glomerulus, zG cells are organized as rosettes, a multicellular structure widely used throughout development to mediate epithelial remodeling, but not often found in healthy adult tissues. Rosettes arise by constriction at a common cellular contact point mediated/facilitated by adherens junctions (AJs). In mice, small, dispersed AJs first appear postnatally and enrich along the entire cell-cell contact around 10 days after birth. Subsequently, these AJ-rich contacts contract, allowing rosettes to form. Concurrently, flat sheet-like domains in the nascent zG, undergo invagination and folding, gradually giving rise to the compact round glomeruli that comprise the adult zG. How these structures impact adrenal function is discussed.
Identifiants
pubmed: 33891993
pii: S0303-7207(21)00131-3
doi: 10.1016/j.mce.2021.111287
pmc: PMC8159910
mid: NIHMS1696695
pii:
doi:
Substances chimiques
Laminin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111287Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK034854
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK123694
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL036977
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138241
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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