Comparisons of PNEC derivation logic flows under example regulatory schemes and implications for ecoTTC.
Aquatic
Hazard
Predicted No Effect concentration
Statistic
Threshold of toxicologic concern
Journal
Regulatory toxicology and pharmacology : RTP
ISSN: 1096-0295
Titre abrégé: Regul Toxicol Pharmacol
Pays: Netherlands
ID NLM: 8214983
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
31
01
2021
revised:
07
04
2021
accepted:
12
04
2021
pubmed:
24
4
2021
medline:
15
12
2021
entrez:
23
4
2021
Statut:
ppublish
Résumé
Derivation of Predicted No Effect Concentrations (PNECs) for aquatic systems is the primary deterministic form of hazard extrapolation used in environmental risk assessment. Depending on the data availability, different regulatory jurisdictions apply application factors (AFs) to the most sensitive measured endpoint to derive the PNEC for a chemical. To assess differences in estimated PNEC values, two PNEC determination methodologies were applied to a curated public database using the EnviroTox Platform (www.EnviroToxdatabase.org). PNECs were derived for 3647 compounds using derivation procedures based on example US EPA and a modified European Union chemical registration procedure to allow for comparisons. Ranked probability distributions of PNEC values were developed and 5th percentile values were calculated for the entire dataset and scenarios where full acute or full chronic data sets were available. The lowest PNEC values indicated categorization based on chemical attributes and modes of action would lead to improved extrapolations. Full acute or chronic datasets gave measurably higher 5th percentile PNEC values. Algae were under-represented in available ecotoxicity data but drove PNECs disproportionately. Including algal inhibition studies will be important in understanding chemical hazards. The PNEC derivation logic flows are embedded in the EnviroTox Platform providing transparent and consistent PNEC derivations and PNEC distribution calculations.
Identifiants
pubmed: 33891999
pii: S0273-2300(21)00073-8
doi: 10.1016/j.yrtph.2021.104933
pmc: PMC10461128
mid: NIHMS1925143
pii:
doi:
Substances chimiques
Hazardous Substances
0
Water Pollutants, Chemical
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104933Subventions
Organisme : Intramural EPA
ID : EPA999999
Pays : United States
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
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