Novel molecular markers of cardiovascular disease risk in type 2 diabetes mellitus.

Biomarkers / metabolism Blood Glucose / metabolism Cardiovascular Diseases / etiology Diabetes Mellitus, Type 2 / complications Humans Reactive Oxygen Species / metabolism Risk Factors
Cardiovascular risk Glycation Inflammation Novel biomarkers Oxidative stress Type 2 diabetes mellitus

Journal

Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730

Informations de publication

Date de publication:
01 08 2021
Historique:
received: 22 09 2020
revised: 15 03 2021
accepted: 13 04 2021
pubmed: 24 4 2021
medline: 18 11 2021
entrez: 23 4 2021
Statut: ppublish

Résumé

Diabetes represents the leading risk factor for the development of cardiovascular disease (CVD). Chronic hyperglycemia and/or acute post-prandial changes in blood glucose determine an increase in reactive oxygen species (ROS), which play a fundamental role in endothelial dysfunction and in the nuclear transport of pro-atherogenic transcription factors that activate the "inflammasome". In addition, the glycemic alteration favors the formation and stabilization of atherosclerotic plaque through the mechanism of non-enzymatic glycation of different molecules, with the establishment of the so-called "advanced glycosylation end products" (AGE). Laboratory information provided by the level of biomarkers could make a quantitative and qualitative contribution to the clinical process of screening, prediction, prevention, diagnosis, prognosis and monitoring of cardiovascular (CV) risk linked to diabetes. This review describes the importance of specific biomarkers, with particular focus on novel ones, for stratifying and management of diabetes CV risk.

Identifiants

DOI: 10.1016/j.bbadis.2021.166148 PMID: 33892081
pubmed: 33892081
pii: S0925-4439(21)00081-8
doi: 10.1016/j.bbadis.2021.166148
pii:
doi:

Substances chimiques

Biomarkers 0
Blood Glucose 0
Reactive Oxygen Species 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

166148

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Rosaria Vincenza Giglio (RV)

Department of Biomedicine, Neuroscience, and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine, and Laboratory Medicine, University of Palermo, Palermo, Italy.

Anca Pantea Stoian (AP)

Faculty of General Medicine, Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University, Bucharest, Romania.

Martin Haluzik (M)

Centre for Experimental Medicine and Department of Diabetes, Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.

Kalliopi Pafili (K)

Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece.

Angelo Maria Patti (AM)

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy. Electronic address: pattiangelomaria@gmail.com.

Ali Abbas Rizvi (AA)

Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, Georgia, USA; Division of Endocrinology, Diabetes and Metabolism, University of South Carolina School of Medicine Columbia, South Carolina, USA.

Marcello Ciaccio (M)

Department of Biomedicine, Neuroscience, and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine, and Laboratory Medicine, University of Palermo, Palermo, Italy; Department of Laboratory Medicine, University-Hospital, Palermo, Italy.

Nikolaos Papanas (N)

Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece.

Manfredi Rizzo (M)

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy; Division of Endocrinology, Diabetes and Metabolism, University of South Carolina School of Medicine Columbia, South Carolina, USA.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Novel molecular markers of cardiovascular...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Novel molecular markers of cardiovascular...
questionsmedicales.fr › Maladies cardiovasculaires › Novel molecular markers of cardiovascular...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Novel molecular markers of cardiovascular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Novel molecular markers of cardiovascular...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Novel molecular markers of cardiovascular...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Novel molecular markers of cardiovascular...