The influence of rs53576 polymorphism in the oxytocin receptor (


Journal

Reviews in the neurosciences
ISSN: 2191-0200
Titre abrégé: Rev Neurosci
Pays: Germany
ID NLM: 8711016

Informations de publication

Date de publication:
27 01 2022
Historique:
received: 09 03 2021
accepted: 27 03 2021
pubmed: 24 4 2021
medline: 5 4 2022
entrez: 23 4 2021
Statut: epublish

Résumé

Empathy is essential for navigating complex social environments. Prior work has shown associations between rs53576, a single nucleotide polymorphism (SNP) located in the oxytocin receptor gene (

Identifiants

pubmed: 33892530
pii: revneuro-2021-0038
doi: 10.1515/revneuro-2021-0038
doi:

Substances chimiques

OXTR protein, human 0
Receptors, Oxytocin 0

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

43-57

Informations de copyright

© 2021 Walter de Gruyter GmbH, Berlin/Boston.

Références

Atkins, D., Uskul, A.K., and Cooper, N.R. (2016). Culture shapes empathic responses to physical and social pain. Emotion 16: 587–601, https://doi.org/10.1037/emo0000162.
Bailey, P.E., Henry, J.D., and Von Hippel, W. (2008). Empathy and social functioning in late adulthood. Aging Ment. Health 12: 499–503, https://doi.org/10.1080/13607860802224243.
Baldner, C. and McGinley, J.J. (2014). Correlational and exploratory factor analyses (EFA) of commonly used empathy questionnaires: new insights. Motiv. Emot. 38: 727–744, https://doi.org/10.1007/s11031-014-9417-2.
Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., and Plumb, I. (2001). The “reading the mind in the Eyes” test revised version: a study with normal adults, and adults with asperger syndrome or high-functioning autism. JCPP (J. Child Psychol. Psychiatry) 42: 241–251.
Batson, C.D., Sager, K., Garst, E., Kang, M., Rubchinsky, K., and Dawson, K. (1997). Is empathy-induced helping due to self-other merging? J. Pers. Soc. Psychol. 73: 495–509, https://doi.org/10.1037/0022-3514.73.3.495.
Buffone, A.E.K. and Poulin, M.J. (2014). Empathy, target distress, and neurohormone genes interact to predict aggression for others–even without provocation. Pers. Soc. Psychol. Bull. 40: 1406–1422, https://doi.org/10.1177/0146167214549320.
Butovskaya, P.R., Lazebny, O.E., Sukhodolskaya, E.M., Vasiliev, V.A., Dronova, D.A., Fedenok, J.N., Rosa, A., Peletskaya, E.N., Ryskov, A.P., and Butovskaya, M.L. (2016). Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe. BMC Genet. 17: 17, https://doi.org/10.1186/s12863-015-0323-8.
Chen, F.S., Kumsta, R., von Dawans, B., Monakhov, M., Ebstein, R.P., and Heinrichs, M. (2011). Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans. Proc. Natl. Acad. Sci. Unit. States Am. 108: 19937–19942, https://doi.org/10.1073/pnas.1113079108.
Chiao, J.Y. (2011). Towards a cultural neuroscience of empathy and prosociality. Emot. Rev. 3: 111–112, https://doi.org/10.1177/1754073910384159.
Chiao, J.Y. and Mathur, V.A. (2016). Cultural neuroscience of pain and empathy. In: Chiao, J.Y., Li, S.-C., Seligman, R., and Turner, R. (Eds.), The Oxford handbook of cultural neuroscience. Oxford University Press, New York, NY, USA, pp. 271–275.
Christ, C.C., Carlo, G., and Stoltenberg, S.F. (2016). Oxytocin receptor (OXTR) single nucleotide polymorphisms indirectly predict prosocial behavior through perspective taking and empathic concern: OXTR and prosocial behavior. J. Pers. 84: 204–213, https://doi.org/10.1111/jopy.12152.
Cohen, J. (1962). The statistical power of abnormal-social psychological research: a review. J. Abnorm. Soc. Psychol. 65: 145–153, https://doi.org/10.1037/h0045186.
Das, S., Forer, L., Schönherr, S., Sidore, C., Locke, A.E., Kwong, A., Vrieze, S.I., Chew, E.Y., Levy, S., McGue, M., . (2016). Next-generation genotype imputation service and methods. Nat. Genet. 48: 1284–1287, https://doi.org/10.1038/ng.3656.
Davis, M.H. (1980). A multidimensional approach to individual differences in empathy. JSAS Catalog Sel. Documents Psychol. 10: 85.
Davis, M.H. (1983). Measuring individual differences in empathy: evidence for a multidimensional approach. J. Pers. Soc. Psychol. 44: 113–126, https://doi.org/10.1037/0022-3514.44.1.113.
Davis, M.H., Luce, C., and Kraus, S.J. (1994). The heritability of characteristics associated with dispositional empathy. J. Pers. 62: 369–391, https://doi.org/10.1111/j.1467-6494.1994.tb00302.x.
Decety, J. (2010). The neurodevelopment of empathy in humans. Dev. Neurosci. 32: 257–267, https://doi.org/10.1159/000317771.
Decety, J. and Jackson, P.L. (2004). The functional architecture of human empathy. Behav. Cognit. Neurosci. Rev. 3: 71–100, https://doi.org/10.1177/1534582304267187.
Demichelis, O.P., Coundouris, S.P., Grainger, S.A., and Henry, J.D. (2020). Empathy and theory of mind in Alzheimer’s disease: a meta-analysis. J. Int. Neuropsychol. Soc.: 26: 963–977, https://doi.org/10.1017/S1355617720000478.
Dermody, N., Wong, S., Ahmed, R., Piguet, O., Hodges, J.R., and Irish, M. (2016). Uncovering the neural bases of cognitive and affective empathy deficits in Alzheimer’s disease and the behavioral-variant of frontotemporal dementia. J. Alzheim. Dis. 53: 801–816, https://doi.org/10.3233/jad-160175.
Dunbar, R.I.M. (2009). The social brain hypothesis and its implications for social evolution. Ann. Hum. Biol. 36: 562–572, https://doi.org/10.1080/03014460902960289.
Dziobek, I., Rogers, K., Fleck, S., Bahnemann, M., Heekeren, H.R., Wolf, O.T., and Convit, A. (2008). Dissociation of cognitive and emotional empathy in adults with asperger syndrome using the multifaceted empathy test (MET). J. Autism Dev. Disord. 38: 464–473, https://doi.org/10.1007/s10803-007-0486-x.
Egger, M., Smith, G.D., Schneider, M., and Minder, C. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629–634, https://doi.org/10.1136/bmj.315.7109.629.
Eisenberg, N., Eggum, N.D., and Di Giunta, L. (2010). Empathy-related responding: associations with prosocial behavior, aggression, and intergroup relations: empathy-related responding. Soc. Issues Policy Rev. 4: 143–180, https://doi.org/10.1111/j.1751-2409.2010.01020.x.
Flasbeck, V., Moser, D., Kumsta, R., and Brüne, M. (2018). The OXTR single-nucleotide polymorphism rs53576 moderates the impact of childhood maltreatment on empathy for social pain in female participants: evidence for differential susceptibility. Front. Psychiatr. 9: 359, https://doi.org/10.3389/fpsyt.2018.00359.
Folstein, M.F., Folstein, S.E., and McHugh, P.R. (1975). “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12: 189–198, https://doi.org/10.1016/0022-3956(75)90026-6.
Gong, P., Fan, H., Liu, J., Yang, X., Zhang, K., and Zhou, X. (2017). Revisiting the impact of OXTR rs53576 on empathy: a population-based study and a meta-analysis. Psychoneuroendocrinology 80: 131–136, https://doi.org/10.1016/j.psyneuen.2017.03.005.
Grainger, S.A., Henry, J.D., Steinvik, H.R., Vanman, E.J., Rendell, P.G., and Labuschagne, I. (2018). Intranasal oxytocin does not reduce age-related difficulties in social cognition. Horm. Behav. 99: 25–34, https://doi.org/10.1016/j.yhbeh.2018.01.009.
Grühn, D., Rebucal, K., Diehl, M., Lumley, M., and Labouvie-Vief, G. (2008). Empathy across the adult lifespan: longitudinal and experience-sampling findings. Emotion 8: 753–765, https://doi.org/10.1037/a0014123.
Hatemi, P.K., Smith, K., Alford, J.R., Martin, N.G., and Hibbing, J.R. (2015). The genetic and environmental foundations of political, psychological, social, and economic behaviors: a panel study of twins and families. Twin Res. Hum. Genet. 18: 243–255, https://doi.org/10.1017/thg.2015.13.
Henry, J.D., von Hippel, W., Molenberghs, P., Lee, T., and Sachdev, P.S. (2016). Clinical assessment of social cognitive function in neurological disorders. Nat. Rev. Neurol. 12: 28–39, https://doi.org/10.1038/nrneurol.2015.229.
Huetter, F.K., Bachmann, H.S., Reinders, A., Siffert, D., Stelmach, P., Knop, D., Horn, P.A., and Siffert, W. (2016). Association of a common oxytocin receptor gene polymorphism with self-reported ‘empathic concern’ in a large population of healthy volunteers. PloS One 11: e0160059, https://doi.org/10.1371/journal.pone.0160059.
Inoue, T., Kimura, T., Azuma, C., Inazawa, J., Takemura, M., Kikuchi, T., Kubota, Y., Ogita, K., and Saji, F. (1994). Structural organization of the human oxytocin receptor gene. J. Biol. Chem. 269: 32451–32456, https://doi.org/10.1016/s0021-9258(18)31656-9.
Kim, H.S., Sherman, D.K., Sasaki, J.Y., Xu, J., Chu, T.Q., Ryu, C., Suh, E.M., Graham, K., and Taylor, S.E. (2010). Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proc. Natl. Acad. Sci. Unit. States Am. 107: 15717–15721, https://doi.org/10.1073/pnas.1010830107.
Knafo, A., Zahn-Waxler, C., Van Hulle, C., Robinson, J.L., and Rhee, S.H. (2008). The developmental origins of a disposition toward empathy: genetic and environmental contributions. Emotion 8: 737–752, https://doi.org/10.1037/a0014179.
Krueger, F., Parasuraman, R., Iyengar, V., Thornburg, M., Weel, J., Lin, M., Clarke, E., McCabe, K., and Lipsky, R.H. (2012). Oxytocin receptor genetic variation promotes human trust behavior. Front. Hum. Neurosci. 6: 4, https://doi.org/10.3389/fnhum.2012.00004.
Laursen, H.R., Siebner, H.R., Haren, T., Madsen, K., Grønlund, R., Hulme, O., and Henningsson, S. (2014). Variation in the oxytocin receptor gene is associated with behavioral and neural correlates of empathic accuracy. Front. Behav. Neurosci. 8: 423, https://doi.org/10.3389/fnbeh.2014.00423.
Lerer, E., Levi, S., Salomon, S., Darvasi, A., Yirmiya, N., and Ebstein, R.P. (2008). Association between the oxytocin receptor (OXTR) gene and autism: relationship to vineland adaptive behavior scales and cognition. Mol. Psychiatr. 13: 980–988, https://doi.org/10.1038/sj.mp.4002087.
Liu, J., Gong, P., Li, H., and Zhou, X. (2017). A field study of the association between CD38 gene and altruistic behavior: empathic response as a mediator. Psychoneuroendocrinology 85: 165–171, https://doi.org/10.1016/j.psyneuen.2017.08.010.
Lohmueller, K.E., Pearce, C.L., Pike, M., Lander, E.S., and Hirschhorn, J.N. (2003). Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat. Genet. 33: 177–182, https://doi.org/10.1038/ng1071.
Lucht, M.J., Barnow, S., Sonnenfeld, C., Ulrich, I., Grabe, H.J., Schroeder, W., Völzke, H., Freyberger, H.J., John, U., Herrmann, F.H., . (2013). Associations between the oxytocin receptor gene (OXTR) and “mind-reading” in humans—an exploratory study. Nord. J. Psychiatr. 67: 15–21, https://doi.org/10.3109/08039488.2012.700731.
Luo, S., Li, B., Ma, Y., Zhang, W., Rao, Y., and Han, S. (2015a). Oxytocin receptor gene and racial ingroup bias in empathy-related brain activity. Neuroimage 110: 22–31, https://doi.org/10.1016/j.neuroimage.2015.01.042.
Luo, S., Ma, Y., Liu, Y., Li, B., Wang, C., Shi, Z., Li, X., Zhang, W., Rao, Y., and Han, S. (2015b). Interaction between oxytocin receptor polymorphism and interdependent culture values on human empathy. Soc. Cognit. Affect Neurosci. 10: 1273–1281, https://doi.org/10.1093/scan/nsv019.
Marcus, R.F., Telleen, S., and Roke, E.J. (1979). Relation between cooperation and empathy in young children. Dev. Psychol. 15: 346–347, https://doi.org/10.1037/0012-1649.15.3.346.
Marsh, A.A., Yu, H.H., Pine, D.S., Gorodetsky, E.K., Goldman, D., and Blair, R.J.R. (2012). The influence of oxytocin administration on responses to infant faces and potential moderation by OXTR genotype. Psychopharmacology 224: 469–476, https://doi.org/10.1007/s00213-012-2775-0.
Maurage, P., Lahaye, M., Grynberg, D., Jeanjean, A., Guettat, L., Verellen-Dumoulin, C., Halkin, S., Heeren, A., Billieux, J., and Constant, E. (2016). Dissociating emotional and cognitive empathy in pre-clinical and clinical Huntington’s disease. Psychiatr. Res. 237: 103–108, https://doi.org/10.1016/j.psychres.2016.01.070.
McDonald, N.M., Baker, J.K., and Messinger, D.S. (2016). Oxytocin and parent–child interaction in the development of empathy among children at risk for autism. Dev. Psychol. 52: 735–745, https://doi.org/10.1037/dev0000104.
Mehrabian, A. and Epstein, N. (1972). A measure of emotional empathy. J. Pers. 40: 525–543, https://doi.org/10.1111/j.1467-6494.1972.tb00078.x.
Meixner, F., Montag, C., and Herbert, C. (2019). Affective language, interpretation bias and its molecular genetic variations: exploring the relationship between genetic variations of the OXTR gene (rs53576 and rs2268498) and the emotional evaluation of words related to the self or the other. Front. Psychol. 10: 68, https://doi.org/10.3389/fpsyg.2019.00068.
Montag, C., Brockmann, E.-M., Lehmann, A., Müller, D.J., Rujescu, D., and Gallinat, J. (2012). Association between oxytocin receptor gene polymorphisms and self-rated ‘empathic concern’ in schizophrenia. PloS One 7: e51882, https://doi.org/10.1371/journal.pone.0051882.
Montag, C., Sindermann, C., Melchers, M., Jung, S., Luo, R., Becker, B., Xie, J., Xu, W., Guastella, A.J., and Kendrick, K.M. (2017). A functional polymorphism of the OXTR gene is associated with autistic traits in Caucasian and Asian populations. Am. J. Med. Genet. Part B: Neuropsychiatric Genetics 174: 808–816, https://doi.org/10.1002/ajmg.b.32596.
Moore, R.C., Dev, S.I., Jeste, D.V., Dziobek, I., and Eyler, L.T. (2015). Distinct neural correlates of emotional and cognitive empathy in older adults. Psychiatr. Res. Neuroimaging 232: 42–50, https://doi.org/10.1016/j.pscychresns.2014.10.016.
Murphy, B.A. and Lilenfield, S.O. (2019). Are self-report cognitive empathy ratings valid proxies for cognitive empathy ability? Negligible meta-analytic relations with behavioral task performance. Psychol. Assess. 31: 1062–1072, https://doi.org/10.1037/pas0000732.
Pearce, E., Wlodarski, R., Machin, A., and Dunbar, R.I.M. (2017). Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality. Proc. Natl. Acad. Sci. Unit. States Am. 114: 5300–5305, https://doi.org/10.1073/pnas.1700712114.
Persico, A.M. (2013). Autisms. In: Neural circuit development and function in the brain. Elsevier, San Diego, CA, USA, pp. 651–694.
Price, A.L., Patterson, N.J., Plenge, R.M., Weinblatt, M.E., Shadick, N.A., and Reich, D. (2006). Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38: 904–909, https://doi.org/10.1038/ng1847.
R Core Team (2019). R: a language and environment for statistical computing. R Foundation for Statistical Computing, Available at: https://www.R-project.org/.
Rankin, K.P., Kramer, J.H., and Miller, B.L. (2005). Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration. Cognit. Behav. Neurol. 18: 28–36, https://doi.org/10.1097/01.wnn.0000152225.05377.ab.
Rodrigues, S.M., Saslow, L.R., Garcia, N., John, O.P., and Keltner, D. (2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc. Natl. Acad. Sci. Unit. States Am. 106: 21437–21441, https://doi.org/10.1073/pnas.0909579106.
Russell, J.A. and Brunton, P.J. (2009). Oxytocin (Peripheral/Central actions and their regulation). In: Encyclopedia of neuroscience. Elsevier, San Diego, CA, USA, pp. 337–347.
Sachdev, P.S., Brodaty, H., Reppermund, S., Kochan, N.A., Trollor, J.N., Draper, B., Slavin, M.J., Crawford, J., Kang, K., and Broe, G.A., . (2010). The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70–90 years. Int. Psychogeriatr. 22: 1248–1264, https://doi.org/10.1017/s1041610210001067.
Schwarzer, G. (2019). Meta: general package for meta-analysis (4.9-5) [computer software], Available at: https://CRAN.R-project.org/package=meta.
Shamay-Tsoory, S.G., Aharon-Peretz, J., and Perry, D. (2009). Two systems for empathy: a double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. Brain 132: 617–627, https://doi.org/10.1093/brain/awn279.
Smith, K.E., Porges, E.C., Norman, G.J., Connelly, J.J., and Decety, J. (2014). Oxytocin receptor gene variation predicts empathic concern and autonomic arousal while perceiving harm to others. Soc. Neurosci. 9: 1–9, https://doi.org/10.1080/17470919.2013.863223.
Sucksmith, E., Allison, C., Baron-Cohen, S., Chakrabarti, B., and Hoekstra, R.A. (2013). Empathy and emotion recognition in people with autism, first-degree relatives, and controls. Neuropsychologia 51: 98–105, https://doi.org/10.1016/j.neuropsychologia.2012.11.013.
Taschereau-Dumouchel, V., Hétu, S., Bagramian, A., Labrecque, A., Racine, M., Chagnon, Y.C., and Jackson, P.L. (2016). BDNF Val66Met polymorphism is associated with self-reported empathy. PloS One 11: e0149911, https://doi.org/10.1371/journal.pone.0149911.
Taylor, S.E., Sherman, D.K., Kim, H.S., Jarcho, J., Takagi, K., and Dunagan, M.S. (2004). Culture and social support: who seeks it and why? J. Pers. Soc. Psychol. 87: 354–362, https://doi.org/10.1037/0022-3514.87.3.354.
Toccaceli, V., Fagnani, C., Eisenberg, N., Alessandri, G., Vitale, A., and Stazi, M.A. (2018). Adult empathy: possible gender differences in gene-environment architecture for cognitive and emotional components in a large Italian twin sample. Twin Res. Hum. Genet. 21: 214–226, https://doi.org/10.1017/thg.2018.19.
Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B.A., Mattay, V.S., Weinberger, D.R., and Meyer-Lindenberg, A. (2010). A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proc. Natl. Acad. Sci. Unit. States Am. 107: 13936–13941, https://doi.org/10.1073/pnas.1003296107.
Uzefovsky, F., Shalev, I., Israel, S., Edelman, S., Raz, Y., Mankuta, D., Knafo-Noam, A., and Ebstein, R.P. (2015). Oxytocin receptor and vasopressin receptor 1a genes are respectively associated with emotional and cognitive empathy. Horm. Behav. 67: 60–65, https://doi.org/10.1016/j.yhbeh.2014.11.007.
Warrier, V., Grasby, K.L., Uzefovsky, F., Toro, R., Smith, P., Chakrabarti, B., Khadake, J., Mawbey-Adamson, E., Litterman, N., and Hottenga, J.-J., . (2018a). Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition. Mol. Psychiatr. 23: 1402–1409, https://doi.org/10.1038/mp.2017.122.
Warrier, V., Toro, R., Chakrabarti, B., the iPSYCH-Broad autism group, Børglum, A.D., Grove, J., the 23andMe Research Team, Hinds, D.A., Bourgeron, T., and Baron-Cohen, S. (2018b). Genome-wide analyses of self-reported empathy: correlations with autism, schizophrenia, and anorexia nervosa. Transl. Psychiatry 8: 35, https://doi.org/10.1038/s41398-017-0082-6.
Weisman, O., Pelphrey, K.A., Leckman, J.F., Feldman, R., Lu, Y., Chong, A., Chen, Y., Monakhov, M., Chew, S.H., and Ebstein, R.P. (2015). The association between 2D:4D ratio and cognitive empathy is contingent on a common polymorphism in the oxytocin receptor gene (OXTR rs53576). Psychoneuroendocrinology 58: 23–32, https://doi.org/10.1016/j.psyneuen.2015.04.007.
Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Shuang, M., Gong, X., Zhang, Y., Yang, X., and Zhang, D. (2005). Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese han population. Biol. Psychiatr. 58: 74–77, https://doi.org/10.1016/j.biopsych.2005.03.013.
Wu, N., Li, Z., and Su, Y. (2012). The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy. J. Affect. Disord. 138: 468–472, https://doi.org/10.1016/j.jad.2012.01.009.
Zhao, J., Yang, Y., Li, X., Zheng, L., Xue, M., Zhang, M., Wang, C., Yu, R., and Gong, P. (2019). OXTR rs53576 polymorphism impacts interpersonal adaptability: dispositional forgiveness as a mediator. Psychoneuroendocrinology 103: 8–13, https://doi.org/10.1016/j.psyneuen.2018.12.240.

Auteurs

Russell J Chander (RJ)

Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.

Karen A Mather (KA)

Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.
Neuroscience Research Australia (NeuRA), Sydney, NSW 2031, Australia.

Rhiagh Cleary (R)

Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.

Sarah A Grainger (SA)

School of Psychology, The University of Queensland, St Lucia, QLD, Australia.

Anbupalam Thalamuthu (A)

Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.

Katya Numbers (K)

Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.

Nicole A Kochan (NA)

Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.

Nicola J Armstrong (NJ)

Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.
Discipline of Mathematics and Statistics, Curtin University, Perth, WA 6102, Australia.

Henry Brodaty (H)

Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.
Dementia Centre for Research Collaboration (DCRC), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.

Julie D Henry (JD)

School of Psychology, The University of Queensland, St Lucia, QLD, Australia.

Perminder S Sachdev (PS)

Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.
Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW 2031, Australia.

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