Body mass index increase in preschoolers with heterogeneous psychiatric diagnoses treated with risperidone.
Age Factors
Antipsychotic Agents
/ administration & dosage
Body Mass Index
Child, Preschool
Dose-Response Relationship, Drug
Female
Follow-Up Studies
Humans
Longitudinal Studies
Male
Mental Disorders
/ drug therapy
Retrospective Studies
Risperidone
/ administration & dosage
Sex Factors
Weight Gain
/ drug effects
Preschool age
dose response
risperidone
weight gain
Journal
Journal of psychopharmacology (Oxford, England)
ISSN: 1461-7285
Titre abrégé: J Psychopharmacol
Pays: United States
ID NLM: 8907828
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
pubmed:
25
4
2021
medline:
3
2
2022
entrez:
24
4
2021
Statut:
ppublish
Résumé
Use of risperidone in preschool-aged children is growing, with rising concerns of adverse metabolic consequences. Longitudinal data on risperidone-related weight gain in preschoolers are scarce. We aimed to evaluate changes in body mass index (BMI) that are associated with risperidone treatment in preschoolers. We analyzed naturalistic, longitudinal data on 141 preschool children (112 boys, 29 girls) receiving psychiatric care. Mean patient age at baseline was 5.0 years (SD=0.8) and average follow-up period was 1.3 years (SD=0.8), with >8 mean BMI measurements per patient. We studied the effect of risperidone exposure ( Risperidone treatment was significantly associated with an increase in BMI (effect size of exposure=0.45 SD (SE=0.06), Similar to older populations, risperidone treatment in preschoolers is associated with significant weight gain, with evidence for dose effects. Findings provide critical data that can inform clinicians.
Identifiants
pubmed: 33892604
doi: 10.1177/02698811211008592
pmc: PMC9426686
mid: NIHMS1832335
doi:
Substances chimiques
Antipsychotic Agents
0
Risperidone
L6UH7ZF8HC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1134-1140Subventions
Organisme : NIMH NIH HHS
ID : K23 MH120437
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001879
Pays : United States
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