Correlates of Neutralization against SARS-CoV-2 Variants of Concern by Early Pandemic Sera.
SARS-CoV-2
T cells
neutralizing antibodies
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
24 06 2021
24 06 2021
Historique:
pubmed:
25
4
2021
medline:
6
7
2021
entrez:
24
4
2021
Statut:
ppublish
Résumé
Emerging SARS-CoV-2 variants of concern that overcome natural and vaccine-induced immunity threaten to exacerbate the COVID-19 pandemic. Increasing evidence suggests that neutralizing antibody (NAb) responses are a primary mechanism of protection against infection. However, little is known about the extent and mechanisms by which natural immunity acquired during the early COVID-19 pandemic confers cross-neutralization of emerging variants. In this study, we investigated cross-neutralization of the B.1.1.7 and B.1.351 SARS-CoV-2 variants in a well-characterized cohort of early pandemic convalescent subjects. We observed modestly decreased cross-neutralization of B.1.1.7 but a substantial 4.8-fold reduction in cross-neutralization of B.1.351. Correlates of cross-neutralization included receptor binding domain (RBD) and N-terminal domain (NTD) binding antibodies, homologous NAb titers, and membrane-directed T cell responses. These data shed light on the cross-neutralization of emerging variants by early pandemic convalescent immune responses.
Identifiants
pubmed: 33893169
pii: JVI.00404-21
doi: 10.1128/JVI.00404-21
pmc: PMC8223959
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0040421Subventions
Organisme : NICHD NIH HHS
ID : K12 HD000849
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002541
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI126603
Pays : United States
Organisme : NIH HHS
ID : R01 OD024917
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI124377
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI128751
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129797
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007387
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA260476
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI051223
Pays : United States
Références
Cell. 2020 Dec 10;183(6):1496-1507.e16
pubmed: 33171099
Lancet. 2021 Jan 9;397(10269):99-111
pubmed: 33306989
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Nature. 2020 Aug;584(7821):450-456
pubmed: 32698192
Nature. 2021 Apr;592(7852):122-127
pubmed: 33636719
Nature. 2020 Oct;586(7830):583-588
pubmed: 32731257
Cell Res. 2021 Jun;31(6):720-722
pubmed: 33893398
Nature. 2021 Apr;592(7853):277-282
pubmed: 33545711
Sci Immunol. 2020 Oct 8;5(52):
pubmed: 33033172
Science. 2020 Aug 7;369(6504):643-650
pubmed: 32540902
Nature. 2020 Aug;584(7821):457-462
pubmed: 32668444
Science. 2021 Aug 13;373(6556):818-823
pubmed: 34016740
Nature. 2021 Apr;592(7852):116-121
pubmed: 33106671
Science. 2020 Aug 7;369(6504):650-655
pubmed: 32571838
Cell. 2020 Nov 12;183(4):996-1012.e19
pubmed: 33010815
Nat Microbiol. 2020 Dec;5(12):1598-1607
pubmed: 33106674
Cell. 2020 Aug 20;182(4):812-827.e19
pubmed: 32697968
Science. 2021 Mar 12;371(6534):1152-1153
pubmed: 33514629
JAMA Intern Med. 2020 Oct 1;180(10):1356-1362
pubmed: 32808970
Sci Immunol. 2020 Dec 7;5(54):
pubmed: 33288645
N Engl J Med. 2021 Feb 11;384(6):533-540
pubmed: 33369366
Cell Host Microbe. 2021 Apr 14;29(4):516-521.e3
pubmed: 33798491
N Engl J Med. 2021 Mar 8;384(15):1466-1468
pubmed: 33684280
Cell Host Microbe. 2021 Mar 10;29(3):477-488.e4
pubmed: 33535027
Nature. 2021 Feb;590(7847):630-634
pubmed: 33276369
Lancet. 2021 Feb 20;397(10275):671-681
pubmed: 33545094
N Engl J Med. 2021 Feb 4;384(5):403-416
pubmed: 33378609
Lancet Infect Dis. 2020 May;20(5):533-534
pubmed: 32087114
Science. 2020 Oct 2;370(6512):89-94
pubmed: 32753554
J Infect Dis. 2021 May 28;223(10):1666-1670
pubmed: 33580259
Science. 2021 Jan 1;371(6524):9-10
pubmed: 33384355
Science. 2020 Dec 4;370(6521):1227-1230
pubmed: 33115920
J Clin Invest. 2020 Nov 2;130(11):6141-6150
pubmed: 32764200
Cell Host Microbe. 2021 Jan 13;29(1):23-31.e4
pubmed: 33306985
Nat Med. 2021 Apr;27(4):717-726
pubmed: 33664494
N Engl J Med. 2021 Mar 17;384(15):1468-1470
pubmed: 33730471
Nat Immunol. 2020 Nov;21(11):1336-1345
pubmed: 32887977
Cell. 2020 Nov 12;183(4):1024-1042.e21
pubmed: 32991844
JAMA Intern Med. 2021 May 1;181(5):672-679
pubmed: 33625463
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
Nature. 2021 May;593(7857):130-135
pubmed: 33684923
Lancet. 2021 Mar 13;397(10278):952-954
pubmed: 33581803