Human Nasal and Lung Tissues Infected
Animals
COVID-19
/ immunology
Chlorocebus aethiops
Dogs
Humans
Immunity, Innate
Influenza, Human
/ immunology
Lung
/ immunology
Madin Darby Canine Kidney Cells
Nasal Mucosa
/ immunology
Organ Specificity
/ immunology
RNA, Messenger
/ immunology
RNA, Viral
/ immunology
SARS-CoV-2
/ immunology
Vero Cells
COVID-19
SARS-CoV-2
human respiratory viruses
nasal mucosa
organ culture
tissue innate immune response
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
24 06 2021
24 06 2021
Historique:
pubmed:
25
4
2021
medline:
6
7
2021
entrez:
24
4
2021
Statut:
ppublish
Résumé
The nasal mucosa constitutes the primary entry site for respiratory viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While the imbalanced innate immune response of end-stage coronavirus disease 2019 (COVID-19) has been extensively studied, the earliest stages of SARS-CoV-2 infection at the mucosal entry site have remained unexplored. Here, we employed SARS-CoV-2 and influenza virus infection in native multi-cell-type human nasal turbinate and lung tissues
Identifiants
pubmed: 33893170
pii: JVI.00130-21
doi: 10.1128/JVI.00130-21
pmc: PMC8223920
doi:
Substances chimiques
RNA, Messenger
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0013021Subventions
Organisme : Israeli Ministry of Science & Technology
ID : 3-16964
Organisme : 7th Framework Program ERA-NET
Organisme : Israeli Science Ministry
Organisme : Israel Science Foundation (ISF)
ID : 530/18
Organisme : Rothschild Foundation Hanadiv Europe (Rothschild Foundation (Europe))
Organisme : Samueli Institute (Samueli Institute for Information Biology)
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