Food groups associated with immune-mediated inflammatory diseases: a Mendelian randomization and disease severity study.

Crohn Disease Humans Inflammatory Bowel Diseases / genetics Lupus Erythematosus, Systemic Mendelian Randomization Analysis Severity of Illness Index

Journal

European journal of clinical nutrition

ISSN: 1476-5640

Titre abrégé: Eur J Clin Nutr

Pays: England

ID NLM: 8804070

Informations de publication

Date de publication:
09 2021

Historique:

received: 26 07 2020

accepted: 29 03 2021

revised: 17 03 2021

pubmed: 25 4 2021

medline: 26 7 2022

entrez: 24 4 2021

Statut: ppublish

Résumé

Immune-mediated inflammatory diseases (IMIDs) are prevalent diseases. There is, however, a lack of understanding of the link between diet and IMIDs, how much dietary patterns vary between them and if there are food groups associated with a worsening of the disease. To answer these questions we analyzed a nation-wide cohort of n = 11,308 patients from six prevalent IMIDs and 2050 healthy controls. We compared their weekly intake of the major food categories, and used a Mendelian randomization approach to determine which dietary changes are caused by disease. Within each IMID, we analyzed the association between food frequency and disease severity. After quality control, n = 11,230 recruited individuals were used in this study. We found that diet is profoundly altered in all IMIDs: at least three food categories are significantly altered in each disease (P < 0.05). Inflammatory bowel diseases showed the largest differences compared to controls (n ≥ 8 categories, P < 0.05). Mendelian randomization analysis supported that some of these dietary changes, like vegetable reduction in Crohn's Disease (P = 2.5 × 10 This cross-disease study demonstrates that prevalent IMIDs are associated to a significant change in the normal dietary patterns. This variation is highly disease-specific and, in some cases, it is caused by the disease itself. Severity in IMIDs is also associated with specific food groups. The results of this study underscore the importance of studying diet in IMIDs.

Sections du résumé

BACKGROUND/OBJECTIVES

SUBJECTS/METHODS

To answer these questions we analyzed a nation-wide cohort of n = 11,308 patients from six prevalent IMIDs and 2050 healthy controls. We compared their weekly intake of the major food categories, and used a Mendelian randomization approach to determine which dietary changes are caused by disease. Within each IMID, we analyzed the association between food frequency and disease severity.

RESULTS

After quality control, n = 11,230 recruited individuals were used in this study. We found that diet is profoundly altered in all IMIDs: at least three food categories are significantly altered in each disease (P < 0.05). Inflammatory bowel diseases showed the largest differences compared to controls (n ≥ 8 categories, P < 0.05). Mendelian randomization analysis supported that some of these dietary changes, like vegetable reduction in Crohn's Disease (P = 2.5 × 10

CONCLUSIONS

This cross-disease study demonstrates that prevalent IMIDs are associated to a significant change in the normal dietary patterns. This variation is highly disease-specific and, in some cases, it is caused by the disease itself. Severity in IMIDs is also associated with specific food groups. The results of this study underscore the importance of studying diet in IMIDs.

Identifiants

DOI: 10.1038/s41430-021-00913-6 PMID: 33893449

pubmed: 33893449

doi: 10.1038/s41430-021-00913-6

pii: 10.1038/s41430-021-00913-6

doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

1368-1382

Investigateurs

Eduardo Fonseca (E)

Jesús Rodríguez (J)

Patricia Carreira (P)

Valle García (V)

José A Pinto-Tasende (JA)

Lluís Puig (L)

Elena Ricart (E)

Francisco Blanco (F)

Jordi Gratacós (J)

Ricardo Blanco (R)

Víctor Martínez Taboada (VM)

Emilia Fernández (E)

Pablo Unamuno (P)

Isidoro González (I)

Fernando Gomollón García (FG)

Raimon Sanmartí (R)

Ana Gutiérrez (A)

Àlex Olivé (À)

José Luís López Estebaranz (JLL)

Esther García-Planella (E)

Juan Carlos Torre-Alonso (JC)

José Luis Andreu (JL)

David Moreno Ramírez (DM)

Benjamín Fernández (B)

Mª Ángeles Aguirre Zamorano (MÁA)

Pablo de la Cueva (P)

Pilar Nos Mateu (PN)

Paloma Vela (P)

Francisco Vanaclocha (F)

Héctor Coromines (H)

Santiago Muñoz (S)

Joan Miquel Nolla (JM)

Enrique Herrera (E)

Carlos González (C)

José Luis Marenco de la Fuente (JLM)

Maribel Vera (M)

Alba Erra (A)

Daniel Roig (D)

Antonio Zea (A)

María Esteve Comas (ME)

Carles Tomàs (C)

Pedro Zarco (P)

José María Pego (JM)

Cristina Saro (C)

Antonio González (A)

Mercedes Freire (M)

Alicia García (A)

Elvira Díez (E)

Georgina Salvador (G)

César Díaz (C)

Simón Sánchez (S)

Alfredo Willisch Dominguez (AW)

José Antonio Mosquera (JA)

Julio Ramírez (J)

Esther Rodríguez Almaraz (ER)

Núria Palau (N)

Raül Tortosa (R)

Mireia López (M)

Andrea Pluma (A)

Adrià Aterido (A)

Informations de copyright

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